US 10,376,489 B2
Wound healing
Manuela Martins-Green, Riverside, CA (US); Sandeep Dhall, Elkridge, MD (US); Danh Do, Baltimore, MD (US); and Neal Schiller, Riverside, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US)
Filed on Apr. 20, 2017, as Appl. No. 15/492,649.
Application 15/492,649 is a continuation of application No. 15/162,570, filed on May 23, 2016, abandoned.
Claims priority of provisional application 62/165,156, filed on May 21, 2015.
Prior Publication US 2017/0252320 A1, Sep. 7, 2017
Int. Cl. A61K 31/355 (2006.01); A61K 31/198 (2006.01); A61K 45/06 (2006.01); A61L 15/44 (2006.01); A61L 26/00 (2006.01)
CPC A61K 31/355 (2013.01) [A61K 31/198 (2013.01); A61K 45/06 (2013.01); A61L 15/44 (2013.01); A61L 26/0066 (2013.01); A61L 2300/412 (2013.01)] 12 Claims
 
1. A method of treating a mouse to cause it to have a chronic wound whereby the mouse can be used as an animal model, comprising
creating a fresh wound in a mouse,
inhibiting at least two antioxidant agents located within the fresh wound, and
allowing the fresh wound to develop into a chronic wound,
wherein the inhibiting is performed by administering to the mouse one or more inhibitors of the at least one antioxidant agent, where the one or more inhibitors is an inhibitor of catalase, an inhibitor of glutathione peroxidase, or a combination thereof.