US 10,376,488 B2
Use of flavonoids in manufacturing compositions for wound healing
Wei-Luen Chang, Taipei (TW); and Mo-Chi Cheng, Taipei (TW)
Assigned to ONENESS BIOTECH CO., LTD, Taipei (TW)
Appl. No. 15/509,121
Filed by ONENESS BIOTECH CO., Ltd, Taipei (TW)
PCT Filed Sep. 5, 2014, PCT No. PCT/CN2014/086034
§ 371(c)(1), (2) Date Mar. 6, 2017,
PCT Pub. No. WO2016/033802, PCT Pub. Date Mar. 10, 2016.
Prior Publication US 2017/0273938 A1, Sep. 28, 2017
Int. Cl. A61K 31/352 (2006.01)
CPC A61K 31/352 (2013.01) 4 Claims
1. A method for healing a chronic wound comprising topically administering to a patient in need thereof a therapeutically effective amount of a compound of the structure as shown in the general formula I:

OG Complex Work Unit Drawing
wherein A is a hydrogen atom, R or —OH;
n1 and n2 are the same or different, being an integer of 0 to 4, wherein the sum of n1 and n2 is equal to or less than 4;
n3 and n4 are the same or different, being an integer of 0 to 5, wherein the sum of n3 and n4 is equal to or less than 5;
wherein R, R1, R2, R3 or R4 is a hydrogen atom, or an alkyl group having 1 to 3 carbon atoms, and
wherein the compound is a non-glycosylated flavone.