US 10,376,483 B2
Bolus dose of hydroxycitric acid with glycerol
Dallas L. Clouatre, Seattle, WA (US); Daniel E. Clouatre, Seattle, WA (US); and Brad J. Douglass, Seattle, WA (US)
Assigned to Glykon Technologies Group, LLC, Seattle, WA (US)
Filed by Glykon Technologies Group, LLC, Seattle, WA (US)
Filed on May 9, 2018, as Appl. No. 15/975,424.
Application 15/975,424 is a continuation of application No. 15/701,107, filed on Sep. 11, 2017, granted, now 9,993,448.
Application 15/701,107 is a continuation of application No. 14/614,201, filed on Feb. 4, 2015, granted, now 9,789,076, issued on Oct. 17, 2017.
Claims priority of provisional application 62/081,161, filed on Nov. 18, 2014.
Prior Publication US 2018/0256527 A1, Sep. 13, 2018
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 36/00 (2006.01); A61K 31/194 (2006.01); A61K 47/10 (2017.01); A61K 45/06 (2006.01); A61K 36/74 (2006.01); A61K 31/216 (2006.01); A61K 36/42 (2006.01); A61K 36/185 (2006.01); A61K 9/14 (2006.01); A61J 1/14 (2006.01); A61K 9/00 (2006.01); A61K 31/00 (2006.01); A61K 31/047 (2006.01)
CPC A61K 31/194 (2013.01) [A61J 1/1412 (2013.01); A61K 9/0053 (2013.01); A61K 9/0095 (2013.01); A61K 9/14 (2013.01); A61K 9/145 (2013.01); A61K 31/00 (2013.01); A61K 31/047 (2013.01); A61K 31/216 (2013.01); A61K 36/185 (2013.01); A61K 36/42 (2013.01); A61K 36/74 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01)] 12 Claims
 
1. A sealed dosage container, consisting essentially of:
an aqueous solution of a hydroxycitrate salt in combination with glycerol, wherein the hydoxycitrate salt is present in the sealed container in amount of 3.0 g to 4.5 g±20%, and the glycerol is present in the container in an amount in a range of from 1.0 g to 4.0 g±20%, and a therapeutically active agent selected from the group consisting of a green coffee bean extract, a bitter melon extract, and sesame lignan extract, and
wherein the liquid sealed dosage is prepared by a process consisting essentially of the steps of:
mixing glycerol, and purified water wherein the glycerol is present in an amount of about 1 to 3 parts by volume and the purified water is present in an amount of about 3 to 1 parts by volume to create a glycerol and purified water solution; and
dissolving the hydroxycitrate salt in the glycerol and purified water solution to obtain an hydroxycitrate salt concentration ranging from about 1.1 to 1.7 molar dosage; and
adding the active agent.