US 10,376,479 B2
Endoxifen compositions and methods
Ateeq Ahmad, Wadsworth, IL (US); Shoukath M. Ali, Vernon Hills, IL (US); Moghis U. Ahmad, Wadsworth, IL (US); Saifuddin Sheikh, Waukegan, IL (US); and Imran Ahmad, Libertyville, IL (US)
Assigned to Jina Pharmaceuticals, Inc., Libertyville, IL (US)
Filed by Jina Pharmaceuticals, Inc., Libertyville, IL (US)
Filed on Apr. 27, 2016, as Appl. No. 15/139,687.
Application 15/139,687 is a continuation of application No. 12/515,261, granted, now 9,333,190, previously published as PCT/US2007/085443, filed on Nov. 21, 2007.
Claims priority of provisional application 60/860,788, filed on Nov. 22, 2006.
Claims priority of provisional application 60/860,420, filed on Nov. 21, 2006.
Prior Publication US 2016/0346230 A1, Dec. 1, 2016
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 31/138 (2006.01); A61K 9/19 (2006.01); A61K 9/127 (2006.01); A61K 9/00 (2006.01); A61K 31/35 (2006.01); C07D 309/10 (2006.01)
CPC A61K 31/138 (2013.01) [A61K 9/0014 (2013.01); A61K 9/127 (2013.01); A61K 9/19 (2013.01); A61K 9/20 (2013.01); A61K 9/48 (2013.01); A61K 31/35 (2013.01); C07D 309/10 (2013.01)] 1 Claim
OG exemplary drawing
 
1. A method of delivering endoxifen to the plasma of a subject, comprising orally administering to the subject an enteric-coated tablet or enteric-coated capsule containing a pharmaceutical composition comprising an amount of a synthetic preparation of endoxifen effective to deliver endoxifen to the plasma of the subject, wherein:
i) said synthetic preparation of endoxifen is at least 80% Z-endoxifen; and
ii) said synthetic preparation of endoxifen is in the form of a citrate salt.