US 10,376,474 B2
Fentanyl-containing patch for external use
Kunihiko Matsushita, Kagawa (JP); Mamoru Naruse, Tokushima (JP); and Kenichi Hattori, Tokushima (JP)
Assigned to TEIKOKU SEIYAKU CO., LTD., Kagawa (JP)
Filed by TEIKOKU SEIYAKU CO., LTD., Kagawa (JP)
Filed on Nov. 8, 2016, as Appl. No. 15/345,603.
Application 15/345,603 is a continuation of application No. 12/864,932, granted, now 9,517,211, previously published as PCT/JP2009/051172, filed on Jan. 26, 2009.
Claims priority of application No. 2008-015875 (JP), filed on Jan. 28, 2008.
Prior Publication US 2017/0071872 A1, Mar. 16, 2017
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/70 (2006.01); A61K 31/4468 (2006.01); A61P 25/04 (2006.01); A61K 47/06 (2006.01); A61K 47/14 (2017.01); A61K 47/32 (2006.01); A61K 9/00 (2006.01)
CPC A61K 9/7076 (2013.01) [A61K 9/0014 (2013.01); A61K 9/7023 (2013.01); A61K 9/7053 (2013.01); A61K 31/4468 (2013.01); A61K 47/06 (2013.01); A61K 47/14 (2013.01); A61K 47/32 (2013.01)] 1 Claim
 
1. An external patch consisting essentially of an adhesive layer laminated on a support,
wherein said adhesive layer consists essentially of:
a styrene-isoprene-styrene block copolymer (SIS) base component;
a tackifier component, wherein the tackifier component consists essentially of a hydrogenated rosin glycerol ester and an alicyclic saturated hydrocarbon resin;
a softening component consisting of poly-butene and liquid paraffin;
a fatty acid ester component, wherein the fatty acid ester component is isopropyl myristate;
fentanyl; and
optionally one or more ingredients selected from the group consisting of polyvinylpyrrolidone, polyvinylpyrrolidone/vinyl acetate copolymers, titanium dioxide, silica species, and dibutylhydroxytoluene,
wherein:
(1) the amount of said rosin resin is 1 to 5 times as much as the amount by weight of fentanyl,
(2) the amount of said rosin resin is 0.1 to 0.6 times as much as the total amount by weight of the tackifier component,
(3) the amount of said tackifier component is 30 to 60% by weight based upon the total amount of components in the adhesive layer,
(4) the ratio by weight of liquid paraffin to poly-butene is 11:10 to 3:1, and
(5) the amount of said styrene-isoprene-styrene block copolymer (SIS) base component is 10 to 30% by weight, the amount of said softening component is 5 to 40% by weight, the amount of said fatty acid ester component is 1 to 20% by weight, and the amount of said fentanyl is 0.1 to 10% by weight, based upon the total amount of components in the adhesive layer.