US 10,376,473 B2
Transdermal adhesive compositions, devices, and methods
James P. DiZio, St. Paul, MN (US); Elizabeth E. Johnson, Afton, MN (US); Zheng Z. Wu, Santa Clara, CA (US); and Amy Preszler Prince, Woodbury, MN (US)
Assigned to 3M Innovative Properties Company, St. Paul, MN (US)
Filed by 3M INNOVATIVE PROPERTIES COMPANY, St. Paul, MN (US)
Filed on Jul. 23, 2018, as Appl. No. 16/42,361.
Application 15/168,270 is a division of application No. 13/811,343, granted, now 9,375,510, issued on Jun. 28, 2016, previously published as PCT/US2011/044522, filed on Jul. 19, 2011.
Application 16/042,361 is a continuation of application No. 15/168,270, filed on May 31, 2016, granted, now 10,034,840.
Claims priority of provisional application 61/366,358, filed on Jul. 21, 2010.
Prior Publication US 2018/0325838 A1, Nov. 15, 2018
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/70 (2006.01); A61K 31/165 (2006.01); C09J 4/06 (2006.01); C09J 133/08 (2006.01); C09J 133/10 (2006.01); A61K 31/27 (2006.01); A61L 24/06 (2006.01); C08F 220/18 (2006.01)
CPC A61K 9/7061 (2013.01) [A61K 31/165 (2013.01); A61K 31/27 (2013.01); A61L 24/06 (2013.01); C08F 220/18 (2013.01); C09J 4/06 (2013.01); C09J 133/08 (2013.01); C09J 133/10 (2013.01); C08F 2220/1858 (2013.01)] 21 Claims
 
1. A method of delivering at least one pharmaceutically active compound to a subject, the method comprising contacting a transdermal adhesive composition with the subject, wherein the transdermal adhesive composition comprises:
an adhesive comprising a washed polymerization reaction product of at least two ethylenically unsaturated monomers; and
at least one pharmaceutically active compound which is susceptible to oxidative degradation;
wherein the at least two ethylenically unsaturated monomers, if present in the adhesive as unreacted monomers, are present at a level of less than 200 ppm of total unreacted monomer, based upon the total weight of the adhesive;
wherein any free radical initiator, if present in the adhesive, is present at a level of less than 20 ppm, based upon the total weight of the adhesive; and
wherein the composition is essentially free of any added antioxidant.