US 10,376,469 B2
Microspheres containing therapeutic agents and related methods of use
Philippe Reb, Themericourt (FR)
Assigned to Biosphere Medical, Inc., South Jordan, UT (US)
Filed by Biosphere Medical, Inc., South Jordan, UT (US)
Filed on Feb. 17, 2017, as Appl. No. 15/436,451.
Claims priority of provisional application 62/296,430, filed on Feb. 17, 2016.
Prior Publication US 2017/0231915 A1, Aug. 17, 2017
Int. Cl. A61K 9/16 (2006.01); A61K 31/282 (2006.01); A61K 31/555 (2006.01); A61K 33/24 (2019.01); C08F 290/10 (2006.01)
CPC A61K 9/1652 (2013.01) [A61K 9/1635 (2013.01); A61K 9/1694 (2013.01); A61K 31/282 (2013.01); A61K 31/555 (2013.01); A61K 33/24 (2013.01); C08F 290/10 (2013.01)] 19 Claims
 
1. Microspheres suitable for use in therapeutic embolization, comprising:
a biocompatible, polymeric material comprising a copolymer comprising an acrylamide monomer, wherein the acrylamide monomer is selected from N-[tris(hydroxymethyl)methyl]acrylamide and N,N′-methylenebis(acrylamide), and a cyclodextrin; and
a therapeutic agent;
wherein the microspheres comprise a biodegradable portion and a non-biodegradable portion, wherein the biodegradable portion comprises the cyclodextrin, and wherein the microspheres retain a substantially spherical shape after degradation of the biodegradable portion when placed in a patient's body.