| US 10,376,467 B2 | ||
| Process for reconstitution of a solid form of a pharmaceutical composition | ||
| Xavier Payet-Burin, Villard Bonnot (FR) | ||
| Appl. No. 15/112,046 |
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| Filed by UCB BIOPHARMA SPRL, Brussels (BE); and EVEON, Montbonnot-Saint-Martin (FR) | ||
| PCT Filed Jan. 20, 2015, PCT No. PCT/EP2015/050988 § 371(c)(1), (2) Date Jul. 15, 2016, PCT Pub. No. WO2015/107214, PCT Pub. Date Jul. 23, 2015. |
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| Claims priority of application No. 14305070 (EP), filed on Jan. 20, 2014. | ||
| Prior Publication US 2016/0331682 A1, Nov. 17, 2016 | ||
| Int. Cl. A61K 9/19 (2006.01); A61K 9/00 (2006.01); A61K 47/60 (2017.01) | ||
| CPC A61K 9/0095 (2013.01) [A61K 9/19 (2013.01); A61K 47/60 (2017.08)] | 19 Claims |
| 1. A process for reconstitution of a solid form of a pharmaceutical composition, comprising the following in succession: (i) providing the solid form of the pharmaceutical composition in a sealed container, the pressure within the container being an initial pressure comprised between 0.5 Pa and 1.2×105 Pa;
(ii) at a first time point, introducing a solvent into said sealed container and maintaining the resulting pressure pr within the container for a controlled time; and
(iii) at a second time point, before reconstitution is complete, increasing the pressure within the container to a controlled pressure higher than pr until complete reconstitution.
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