US 10,376,465 B2
Monovalent metal cation dry powders for inhalation
Michael M. Lipp, Framingham, MA (US); and Jean C. Sung, Cambridge, MA (US)
Assigned to Pulmatrix Operating Company, Inc., Lexington, MA (US)
Filed by Pulmatrix Operating Company, Inc., Lexington, MA (US)
Filed on Sep. 27, 2016, as Appl. No. 15/277,062.
Application 15/277,062 is a continuation of application No. 13/876,312, granted, now 9,642,798, previously published as PCT/US2011/053829, filed on Sep. 29, 2011.
Claims priority of provisional application 61/387,883, filed on Sep. 29, 2010.
Claims priority of provisional application 61/481,879, filed on May 3, 2011.
Prior Publication US 2017/0143624 A1, May 25, 2017
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/00 (2006.01); A61K 31/137 (2006.01); A61K 31/407 (2006.01); A61K 31/4745 (2006.01); A61K 31/5383 (2006.01); A61K 31/56 (2006.01); A61K 38/00 (2006.01); A61K 38/28 (2006.01); A61K 39/00 (2006.01); A61K 31/439 (2006.01); A61K 31/496 (2006.01); A61K 31/58 (2006.01); A61K 31/7036 (2006.01); A61K 39/395 (2006.01); A61K 47/02 (2006.01); A61K 47/18 (2017.01); C07K 16/00 (2006.01)
CPC A61K 9/0073 (2013.01) [A61K 9/0075 (2013.01); A61K 31/137 (2013.01); A61K 31/407 (2013.01); A61K 31/439 (2013.01); A61K 31/4745 (2013.01); A61K 31/496 (2013.01); A61K 31/5383 (2013.01); A61K 31/56 (2013.01); A61K 31/58 (2013.01); A61K 31/7036 (2013.01); A61K 38/00 (2013.01); A61K 38/28 (2013.01); A61K 39/00 (2013.01); A61K 39/395 (2013.01); A61K 47/02 (2013.01); A61K 47/183 (2013.01); C07K 16/00 (2013.01)] 7 Claims
 
1. A respirable dry powder comprising respirable dry particles that comprise sodium sulfate, leucine, an active agent, wherein said active agent is an anti-fungal, and an optional excipient; wherein the respirable dry powder comprising respirable dry particles is characterized by a volume median geometric diameter (VMGD) at 1 bar as measured using a HELOS/RODOS system between 0.5 microns and 5 microns, a tap density of greater than 0.4 g/cc to about 1.2 g/cc, and a dispersibility ratio of 1 bar/4 bar of about 1.5 or less.