US 10,376,460 B2
Flavoring agent and composition for oral cavity containing same
Koji Miyamoto, Kawasaki (JP); Nobuyuki Yamamoto, Kawasaki (JP); Shunsuke Sakurai, Kawasaki (JP); and Yoshihisa Shimamura, Kawasaki (JP)
Assigned to NOF CORPORATION, Tokyo (JP)
Appl. No. 15/738,991
Filed by NOF CORPORATION, Tokyo (JP)
PCT Filed Jun. 30, 2016, PCT No. PCT/JP2016/069369
§ 371(c)(1), (2) Date Dec. 21, 2017,
PCT Pub. No. WO2017/002981, PCT Pub. Date Jan. 5, 2017.
Claims priority of application No. 2015-131083 (JP), filed on Jun. 30, 2015.
Prior Publication US 2018/0168987 A1, Jun. 21, 2018
Int. Cl. A61K 8/81 (2006.01); A61Q 11/00 (2006.01); C08F 220/36 (2006.01); C08F 230/02 (2006.01); A61K 8/24 (2006.01); A61K 8/34 (2006.01); A61K 8/362 (2006.01); A61K 8/41 (2006.01); A61K 8/43 (2006.01); A61K 8/60 (2006.01); A61K 8/67 (2006.01); A61K 47/32 (2006.01)
CPC A61K 8/8152 (2013.01) [A61K 8/24 (2013.01); A61K 8/347 (2013.01); A61K 8/362 (2013.01); A61K 8/416 (2013.01); A61K 8/43 (2013.01); A61K 8/604 (2013.01); A61K 8/676 (2013.01); A61K 8/8158 (2013.01); A61Q 11/00 (2013.01); C08F 220/36 (2013.01); C08F 230/02 (2013.01); A61K 47/32 (2013.01); A61K 2800/74 (2013.01)] 12 Claims
 
1. A method of reducing an uncomfortable taste in an oral cavity of a subject in need thereof, which comprises
providing a composition comprising a copolymer having a weight average molecular weight of 10,000-5,000,000 and 10-90 mol % of a constitution unit (A1) based on 2-(meth)acryloyloxyethylphosphoryl choline, and
90-10 mol % of at least one kind of constitution unit selected from the group consisting of a constitution unit (B1) based on a (meth)acrylic monomer containing an alkyl group, a constitution unit (B2) based on a (meth)acrylic monomer containing a quaternary ammonium group and a constitution unit (B3) based on a (meth)acrylamide monomer and
contacting the oral cavity with the composition to reduce the uncomfortable taste in the oral cavity.