US 10,376,458 B2
Methods of reducing or eliminating tooth staining by application of stain barrier films
Walter Holberg, Apex, NC (US); and Rhett M. Silverstein, New York, NY (US)
Assigned to Hegemon Enterprises, LLC, Chester, NJ (US)
Filed by Hegemon Enterprises, LLC, Chester, NJ (US)
Filed on Sep. 14, 2015, as Appl. No. 14/853,060.
Application 14/853,060 is a continuation of application No. PCT/US2014/027902, filed on Mar. 14, 2014.
Claims priority of provisional application 61/785,980, filed on Mar. 14, 2013.
Prior Publication US 2016/0000684 A1, Jan. 7, 2016
Int. Cl. A61K 8/73 (2006.01); A61Q 11/00 (2006.01); A61K 8/365 (2006.01); A61K 8/02 (2006.01); A61K 8/25 (2006.01)
CPC A61K 8/732 (2013.01) [A61K 8/0204 (2013.01); A61K 8/25 (2013.01); A61K 8/365 (2013.01); A61Q 11/00 (2013.01); A61K 2800/92 (2013.01)] 26 Claims
 
1. A method for reducing or preventing the staining capacity of a compound to a tooth in a mammalian oral cavity comprising affixing to the tooth surface a film that is pre-formed and that degrades upon exposure to amylase or hydrolytic enzymes within the oral cavity,
wherein the film comprises a starch polymer or copolymer that is formed by crosslinking a starch or starch pre-copolymer, wherein the crosslinking occurs in the presence of at least one mono- or (poly)carboxylic acid, and
wherein the film serves as a barrier that prevents staining of the tooth surface and degrades in the oral cavity within about 1 minute to about 70 minutes after affixation.