US 10,376,456 B2
Concentrated and self-preserving compositions of mild surfactants for transparent and skin-pH personal care formulations
Arpit Wankhade, Amravati (IN); Bhagyesh Jagannath Sawant, Kalyan (IN); Pritesh Mhatre, Raigad (IN); Nirmal Koshti, Piscataway, NJ (US); Pooja Vaidya Kshirsagar, Nagpur (IN); Ashwini Ballal, Navi Mumbai (IN); Anuradha Sharma, Navi Mumbai (IN); and Kumar Raunak, Kamothe (IN)
Assigned to GALAXY SURFACTANT, Navi Mumabi (IN)
Appl. No. 15/559,379
Filed by GALAXY SURFACTANTS LTD., Navi Mumbai (IN)
PCT Filed Aug. 3, 2015, PCT No. PCT/IN2015/000309
§ 371(c)(1), (2) Date Sep. 18, 2017,
PCT Pub. No. WO2016/147196, PCT Pub. Date Sep. 22, 2016.
Claims priority of application No. 865/MUM/2015 (IN), filed on Mar. 16, 2015.
Prior Publication US 2019/0167554 A1, Jun. 6, 2019
Int. Cl. A61K 8/00 (2006.01); A61K 8/58 (2006.01); A61Q 19/10 (2006.01); A61K 8/46 (2006.01); A61K 8/42 (2006.01); A61Q 5/02 (2006.01)
CPC A61K 8/58 (2013.01) [A61K 8/42 (2013.01); A61K 8/466 (2013.01); A61Q 5/02 (2013.01); A61Q 19/10 (2013.01); A61K 2800/5922 (2013.01)] 8 Claims
 
1. A mild surfactant composition comprising;
(i) aqueous blend of O-acyl isethionates of Formula I and monopotassium N-acyl glutamate of Formula II;

OG Complex Work Unit Drawing
wherein, R is selected from C5 to C21 alkyl group, saturated or unsaturated, R1 is selected from H or methyl, X is selected from Na+ or K+ and prepared by the process, comprising steps of
A) reacting more than one equivalence of fatty acid chloride with alkali metal hydroxyalkyl sulphonates to prepare compounds of Formula I,
B) reacting the reaction mass of step (A) (containing the remainder fatty acid chloride) with glutamic acid in the presence of a potassium hydroxide under typical aqueous Schotten Baumann reaction conditions to form compounds of Formula II; wherein, the molar ratio of O-acyl isethionates of Formula I to N-acyl glutamate of Formula II is in range of 1.0:1.0 to 1.0:10.0, and
(ii) 0.5 to 2% by weight mixture of N-undecylenoyl glycine and N-capryloyl glycine;
wherein, the total solids content of the composition is at least 45% w/w and the pH of the said aqueous composition is below 6.5.