US 10,376,317 B2
Method and system for image processing and patient-specific modeling of blood flow
Charles A. Taylor, Menlo Park, CA (US)
Assigned to HeartFlow, Inc., Redwood City, CA (US)
Filed by HeartFlow, Inc., Redwood City, CA (US)
Filed on Aug. 25, 2016, as Appl. No. 15/247,231.
Application 13/014,835 is a division of application No. 13/013,561, filed on Jan. 25, 2011, granted, now 8,315,812, issued on Nov. 20, 2012.
Application 15/247,231 is a continuation of application No. 14/866,098, filed on Sep. 25, 2015, granted, now 9,801,689.
Application 14/866,098 is a continuation of application No. 14/276,442, filed on May 13, 2014, granted, now 9,226,672, issued on Jan. 5, 2016.
Application 14/276,442 is a continuation of application No. 13/658,739, filed on Oct. 23, 2012, granted, now 10,179,030.
Application 13/658,739 is a continuation of application No. 13/014,835, filed on Jan. 27, 2011, granted, now 8,311,747, issued on Nov. 13, 2012.
Claims priority of provisional application 61/404,429, filed on Oct. 1, 2010.
Claims priority of provisional application 61/402,345, filed on Aug. 27, 2010.
Claims priority of provisional application 61/402,308, filed on Aug. 26, 2010.
Claims priority of provisional application 61/401,915, filed on Aug. 20, 2010.
Claims priority of provisional application 61/401,462, filed on Aug. 12, 2010.
Prior Publication US 2016/0364860 A1, Dec. 15, 2016
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 5/02 (2006.01); A61B 5/11 (2006.01); A61B 5/22 (2006.01); A61B 6/00 (2006.01); A61B 6/03 (2006.01); A61B 8/02 (2006.01); A61B 8/04 (2006.01); A61B 8/06 (2006.01); A61B 8/08 (2006.01); A61M 5/00 (2006.01); G06G 7/60 (2006.01); G06K 9/00 (2006.01); G06K 9/46 (2006.01); G06K 9/52 (2006.01); G06K 9/62 (2006.01); G06T 7/00 (2017.01); G06T 7/11 (2017.01); G06T 7/12 (2017.01); G06T 7/13 (2017.01); A61B 34/10 (2016.01); G06F 17/10 (2006.01); A61B 34/00 (2016.01); G16B 5/00 (2019.01); G16B 45/00 (2019.01); A61B 5/026 (2006.01); A61B 5/029 (2006.01); G01R 33/563 (2006.01); A61B 5/107 (2006.01); G06T 17/00 (2006.01); A61B 5/021 (2006.01); G06F 17/50 (2006.01); A61B 5/024 (2006.01); G06F 19/00 (2018.01); G06T 7/20 (2017.01); G06T 11/00 (2006.01); G06T 11/20 (2006.01); A61B 5/055 (2006.01); G06T 17/20 (2006.01); G06T 15/10 (2011.01); G06T 11/60 (2006.01); G06T 7/60 (2017.01); G06T 7/70 (2017.01); G06T 7/73 (2017.01); G06T 7/149 (2017.01); G06T 7/62 (2017.01); G01R 33/56 (2006.01); G16H 10/60 (2018.01); G16H 50/30 (2018.01); G16H 50/50 (2018.01); G16H 30/20 (2018.01); G16H 30/40 (2018.01); G16H 10/40 (2018.01); G16H 50/70 (2018.01); A61B 90/00 (2016.01)
CPC A61B 34/10 (2016.02) [A61B 5/004 (2013.01); A61B 5/0035 (2013.01); A61B 5/0044 (2013.01); A61B 5/02 (2013.01); A61B 5/021 (2013.01); A61B 5/024 (2013.01); A61B 5/026 (2013.01); A61B 5/02007 (2013.01); A61B 5/029 (2013.01); A61B 5/02028 (2013.01); A61B 5/0263 (2013.01); A61B 5/055 (2013.01); A61B 5/1075 (2013.01); A61B 5/1118 (2013.01); A61B 5/22 (2013.01); A61B 5/4848 (2013.01); A61B 5/6852 (2013.01); A61B 5/7246 (2013.01); A61B 5/7275 (2013.01); A61B 5/7278 (2013.01); A61B 5/745 (2013.01); A61B 6/03 (2013.01); A61B 6/032 (2013.01); A61B 6/481 (2013.01); A61B 6/503 (2013.01); A61B 6/504 (2013.01); A61B 6/507 (2013.01); A61B 6/5205 (2013.01); A61B 6/5217 (2013.01); A61B 6/5229 (2013.01); A61B 8/02 (2013.01); A61B 8/04 (2013.01); A61B 8/06 (2013.01); A61B 8/065 (2013.01); A61B 8/481 (2013.01); A61B 8/5223 (2013.01); A61B 8/5261 (2013.01); A61B 34/25 (2016.02); A61M 5/007 (2013.01); G01R 33/5601 (2013.01); G01R 33/5635 (2013.01); G01R 33/56366 (2013.01); G06F 17/10 (2013.01); G06F 17/5009 (2013.01); G06F 17/5018 (2013.01); G06F 19/00 (2013.01); G06F 19/321 (2013.01); G06F 19/324 (2013.01); G06G 7/60 (2013.01); G06K 9/00147 (2013.01); G06K 9/46 (2013.01); G06K 9/4604 (2013.01); G06K 9/52 (2013.01); G06K 9/6215 (2013.01); G06K 9/6267 (2013.01); G06K 9/6298 (2013.01); G06T 7/0012 (2013.01); G06T 7/0014 (2013.01); G06T 7/11 (2017.01); G06T 7/12 (2017.01); G06T 7/13 (2017.01); G06T 7/149 (2017.01); G06T 7/20 (2013.01); G06T 7/60 (2013.01); G06T 7/62 (2017.01); G06T 7/70 (2017.01); G06T 7/73 (2017.01); G06T 7/74 (2017.01); G06T 11/00 (2013.01); G06T 11/001 (2013.01); G06T 11/008 (2013.01); G06T 11/20 (2013.01); G06T 11/60 (2013.01); G06T 15/10 (2013.01); G06T 17/00 (2013.01); G06T 17/005 (2013.01); G06T 17/20 (2013.01); G16B 5/00 (2019.02); G16B 45/00 (2019.02); G16H 10/40 (2018.01); G16H 10/60 (2018.01); G16H 30/20 (2018.01); G16H 30/40 (2018.01); G16H 50/30 (2018.01); G16H 50/50 (2018.01); G16H 50/70 (2018.01); A61B 2034/104 (2016.02); A61B 2034/105 (2016.02); A61B 2034/107 (2016.02); A61B 2034/108 (2016.02); A61B 2090/374 (2016.02); A61B 2090/3762 (2016.02); A61B 2090/3764 (2016.02); A61B 2576/00 (2013.01); A61B 2576/023 (2013.01); G06K 2009/4666 (2013.01); G06T 2200/04 (2013.01); G06T 2207/10012 (2013.01); G06T 2207/10072 (2013.01); G06T 2207/10081 (2013.01); G06T 2207/10088 (2013.01); G06T 2207/10104 (2013.01); G06T 2207/10108 (2013.01); G06T 2207/20036 (2013.01); G06T 2207/20124 (2013.01); G06T 2207/30048 (2013.01); G06T 2207/30104 (2013.01); G06T 2210/41 (2013.01); G06T 2211/404 (2013.01); Y02A 90/22 (2018.01); Y02A 90/26 (2018.01)] 17 Claims
 
1. A method for image processing for predicting a post-stenting blood flow characteristic for a coronary artery stenosis from pre-stenting medical image data, comprising:
determining a patient-specific anatomical model of a patient's coronary arteries from the pre-stenting medical image data of the patient;
simulating blood flow through at least a portion of the patient-specific anatomical model of the coronary arteries using a pressure-loss model, wherein the pressure-loss model simulates blood flow through at least a portion of the patient-specific anatomical model;
determining a target stenosis region of the patient-specific anatomical model corresponding to a stenosis in the patient's coronary arteries;
determining a change in pressure over the target stenosis region in the patient-specific anatomical model of the coronary arteries based on the simulated blood flow;
simulating the insertion of a stent by widening a coronary artery of the patient-specific anatomical model at the target stenosis region; and
determining at least one predicted post-stenting blood flow characteristic value for the target stenosis region by re-simulating blood flow through the patient-specific anatomical model of the coronary arteries using a pressure-loss model, the at least one predicted post-stenting blood flow characteristic value being used to determine whether to place a stent in the patient.