US 10,376,188 B2
Analyte sensing biointerface
Peter C. Simpson, Cardiff, CA (US); and James H. Brauker, Coldwater, MI (US)
Assigned to DexCom, Inc., San Diego, CA (US)
Filed by DexCom, Inc., San Diego, CA (US)
Filed on Sep. 21, 2017, as Appl. No. 15/711,225.
Application 15/711,225 is a continuation of application No. 14/281,697, filed on May 19, 2014, granted, now 9,788,766.
Application 14/281,697 is a continuation of application No. 13/285,880, filed on Oct. 31, 2011, abandoned.
Application 13/285,880 is a continuation of application No. 11/404,929, filed on Apr. 14, 2006, granted, now 8,060,174, issued on Nov. 15, 2011.
Claims priority of provisional application 60/683,923, filed on May 23, 2005.
Claims priority of provisional application 60/671,622, filed on Apr. 15, 2005.
Prior Publication US 2018/0008176 A1, Jan. 11, 2018
Int. Cl. A61B 5/05 (2006.01); A61B 5/145 (2006.01); A61B 5/1486 (2006.01); C12Q 1/00 (2006.01); B33Y 80/00 (2015.01); A61B 5/00 (2006.01)
CPC A61B 5/14532 (2013.01) [A61B 5/1486 (2013.01); A61B 5/14865 (2013.01); C12Q 1/001 (2013.01); C12Q 1/006 (2013.01); A61B 5/0031 (2013.01); B33Y 80/00 (2014.12)] 4 Claims
OG exemplary drawing
 
1. An implantable continuous glucose sensor system, comprising:
a transcutaneous sensor comprising a working electrode configured to measure a signal indicative of a glucose concentration in an interstitial fluid;
a membrane disposed on the working electrode, wherein the membrane comprises a biointerface, wherein the biointerface comprises:
a first bioactive agent, wherein the first bioactive agent is configured to reduce effects from inflammation associated with the working electrode, wherein the first bioactive agent is configured to be released during a first time period; and
a second bioactive agent, wherein the second bioactive agent is different from the first bioactive agent, wherein the second bioactive agent is configured to reduce effects from a continual decline in sensor sensitivity, wherein the second bioactive agent is configured to be released during a second time period, wherein the first time period is different from the second time period, wherein the second time period ends later than the first time period; and
electronics electrically coupled to the working electrode.