US 10,376,161 B2
Finger arterial dilatability testing method, finger arterial dilatability testing device, and finger arterial dilatability testing program
Gohichi Tanaka, Sapporo (JP)
Assigned to SAPPORO MEDICAL UNIVERSITY, Sapporo-shi, Hokkaido (JP)
Appl. No. 14/431,626
Filed by SAPPORO MEDICAL UNIVERSITY, Sapporo-shi, Hokkaido (JP)
PCT Filed Oct. 4, 2013, PCT No. PCT/JP2013/077103
§ 371(c)(1), (2) Date Mar. 26, 2015,
PCT Pub. No. WO2014/054788, PCT Pub. Date Apr. 10, 2014.
Claims priority of application No. 2012-222570 (JP), filed on Oct. 4, 2012.
Prior Publication US 2015/0265166 A1, Sep. 24, 2015
Int. Cl. A61B 5/021 (2006.01); A61B 5/02 (2006.01); A61B 5/022 (2006.01); A61B 5/00 (2006.01); A61B 5/0295 (2006.01); A61B 5/024 (2006.01)
CPC A61B 5/02116 (2013.01) [A61B 5/022 (2013.01); A61B 5/02007 (2013.01); A61B 5/0295 (2013.01); A61B 5/02108 (2013.01); A61B 5/02241 (2013.01); A61B 5/6826 (2013.01); A61B 5/7225 (2013.01); A61B 5/7264 (2013.01); A61B 5/7278 (2013.01); A61B 5/7282 (2013.01); A61B 5/02416 (2013.01); A61B 2560/0475 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A finger arterial dilatability testing method for testing a vasodilation response of finger arteries, the method comprising:
a pulse wave data storage step of storing pulse wave data, the pulse wave data being measured from:
one of the fingers of a first hand of a patient and one of the fingers of a second hand of the patient while being pressed at a predetermined sequence at the time of rest and at the time of reperfusion after a forearm of one of the first and second hands is caused to undergo occlusion, or
a first one and a second one of fingers of one of the first hand and the second hand of the patient while being pressed at the predetermined sequence at the time of rest and at the time of reperfusion after one of the first and second ones of the fingers is caused to undergo occlusion;
a normalized pulse volume (NPV) calculation step of calculating, based on the pulse wave data stored in the pulse wave data storage step during the time of rest and the time of reperfusion, the NPV, which is obtained by dividing the amplitude of an AC component of a pulse wave by the average of a DC component of the pulse wave after storing the pulse wave data, for each heartbeat;
a pulse pressure (PP) data acquisition step of acquiring the PP after calculating the NPV; and
a finger arterial compliance response ratio (FCR ratio) calculation step of calculating the FCR ratio, which is an index representing a vasodilation response of the finger arteries for each heartbeat, the FCR ratio being one of (1) the ratio between compliance indices for the first and second hands at the time of reperfusion normalized by the ratio between the compliance indices for the first and second hands at the time of rest when the pulse wave data is measured from the one of the fingers of the first hand of a patient and the one of the fingers of the second hand of the patient, the compliance index being an index obtained by dividing the NPV calculated in the NPV calculation step by the PP acquired in the pulse pressure data acquisition step, and (2) the ratio between the compliance indices for the first and second ones of the fingers of the one of the first hand and the second hand at the time of reperfusion normalized by the ratio between the compliance indices for the first and second ones of the fingers of the one of the first hand and the second hand at the time of rest when the pulse wave data is measured from the first one and the second one of the fingers of the one of the first hand and the second hand of the patient,
wherein the FCR ratio is expressed by the following Expression (1):
FCR ratio=[ln(CIr/CIc)]y−[ln(CIr/CIc)]x  Expression (1)
where CI: compliance index (=NPV/PP),
r: subscript indicating hand or finger that undergoes occlusion,
c: subscript indicating hand or finger that undergoes no occlusion,
x: subscript indicating the time of rest, and
y: subscript indicating the time of reperfusion, and
the predetermined sequence is an action in which a cuff pressure is increased from zero at a predetermined rate and in which the cuff pressure is released until the cuff pressure returns to zero.