US 10,376,154 B2
Detection of aortic coarctation using photoplethysmography
Robert Koppel, West Hempstead, NY (US); and Meir Nitzan, Bet El (IL)
Assigned to The Feinstein Institute for Medical Research, Manhasset, NY (US); and Jerusalem College of Technology, Jerusalem (IL)
Appl. No. 15/125,203
Filed by The Feinstein Institute For Medical Research, Manhasset, NY (US); and Jerusalem College of Technology, Jerusalem (IL)
PCT Filed Mar. 12, 2015, PCT No. PCT/US2015/020077
§ 371(c)(1), (2) Date Sep. 12, 2016,
PCT Pub. No. WO2015/142603, PCT Pub. Date Sep. 24, 2015.
Claims priority of provisional application 61/954,700, filed on Mar. 18, 2014.
Prior Publication US 2017/0164842 A1, Jun. 15, 2017
Int. Cl. A61B 5/00 (2006.01); A61B 5/02 (2006.01); A61B 5/026 (2006.01); A61B 5/1455 (2006.01); A61B 5/024 (2006.01); A61B 5/0295 (2006.01); G16H 50/30 (2018.01)
CPC A61B 5/02007 (2013.01) [A61B 5/0261 (2013.01); A61B 5/0295 (2013.01); A61B 5/02427 (2013.01); A61B 5/14551 (2013.01); A61B 5/6825 (2013.01); A61B 5/6829 (2013.01); A61B 5/725 (2013.01); A61B 5/7207 (2013.01); A61B 5/7246 (2013.01); A61B 5/7275 (2013.01); A61B 5/7203 (2013.01); A61B 2503/04 (2013.01); A61B 2503/045 (2013.01); G16H 50/30 (2018.01)] 23 Claims
OG exemplary drawing
 
1. A method for detecting an aortic coarctation in an infant comprising:
a) obtaining photoplethysmographic (PPG) signals from a right hand and from a foot of the infant using a photoplethysmograph of at least two channels;
b) selecting a section of the PPG signals without movement noise for analysis, low-pass filtering the PPG signals to reduce high frequency noise, and smoothing the PPG signals using a moving average filter;
c) identifying end-diastolic maxima and minima of systolic decrease for hand PPG pulses and for the foot PPG pulses from the PPG signals, and using the end-diastolic maxima and minima of systolic decrease to determine one or both of the following:
c1) time delay (TD) between the end-diastolic maxima for the hand PPG pulses and the end-diastolic maxima for the foot PPG pulses (f-hTD), and/or
c2) PPG pulse amplitude (AM) between the end-diastolic maxima and minima of systolic decrease for the hand PPG pulses and for the foot PPG pulses;
d) if PPG pulse amplitude (AM) is determined, determining a relative pulse amplitude (rAM) by dividing the AM by the minima of systolic decrease to obtain a rAM for the foot (rAM-F) PPG pulses and a rAM for the hand (rAM-H) PPG pulses;
e) calculating mean and standard deviation (SD) of f-hTD, and/or rAM for the foot (rAM-F) and rAM for the hand (rAM-H) for the PPG pulses in a selected section of PPG pulses, and discarding values deviating from the mean by 2 standard deviations or more from the calculation of the mean;
f) if mean foot rAM-F and mean hand rAM-H are calculated, determining a ratio F/H between mean foot rAM-F and mean hand rAM-H, and/or determining a ratio H/F between mean hand rAM-H and mean foot rAM-F; and optionally, obtaining a multiplication product of H/F times f-hTD and/or a multiplication product of F/H times f-hTD; and
g) detecting the aortic coarctation in the infant if one or more of:
the f-hTD is elevated above normal, or
the ratio F/H is decreased below normal, or
the ratio H/F is increased above normal, or
the product H/F times f-hTD is increased above normal.