US 10,376,150 B2
Interfacing systems, devices, and methods for optical imaging
Andreas H. Hielscher, Brooklyn, NY (US); Molly L. Flexman, New York, NY (US); and Keith Yeager, Jersey City, NJ (US)
Assigned to The Trustees of Columbia University in the City of New York, New York, NY (US)
Appl. No. 14/348,072
Filed by The Trustees of Columbia University in the City of New York, New York, NY (US)
PCT Filed Sep. 28, 2012, PCT No. PCT/US2012/058004
§ 371(c)(1), (2) Date Mar. 28, 2014,
PCT Pub. No. WO2013/049629, PCT Pub. Date Apr. 4, 2013.
Claims priority of provisional application 61/541,503, filed on Sep. 30, 2011.
Prior Publication US 2014/0236003 A1, Aug. 21, 2014
Int. Cl. A61B 5/05 (2006.01); A61B 5/00 (2006.01)
CPC A61B 5/0091 (2013.01) [A61B 5/0064 (2013.01); A61B 5/708 (2013.01); A61B 5/4312 (2013.01); A61B 2562/146 (2013.01)] 22 Claims
OG exemplary drawing
 
1. An interfacing device for optical tomographic imaging of breast tissue, the interfacing device comprising:
a plurality of annular members concentrically arranged in a stacked configuration along an axial direction forming a stack,
each annular member of the plurality of annular members being a monolithic piece having an inner surface facing toward the breast tissue and arranged to contact the breast tissue when the interfacing device is in use,
the inner surface of each annular member having an inner diameter that is different from inner diameters of the other annular members and the inner surface coming into contact with the breast tissue when the interfacing device is in use,
the plurality of annular members being arranged such that their respective inner diameters increase from a first axial end of the stack to an opposite second axial end of the stack,
each of the annular members including a plurality of optical input apertures and optical output apertures on its inner surface, wherein the inner surface is monolithic except for the apertures on the inner surface,
the stack forming an inner region bounded by the inner surfaces of the annular members for receiving the breast tissue for imaging, wherein
the interfacing device further includes a translation device connected to each annular member for displacing each annular member along the axial direction so as to adjust spacing between adjacent annular members in said stack.