US 10,376,146 B2
Miniaturized implantable electrochemical sensor devices
Muhammad Mujeeb-U-Rahman, Pasadena, CA (US); and Axel Scherer, Barnard, VT (US)
Assigned to CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US)
Filed by California Institute of Technology, Pasadena, CA (US)
Filed on Feb. 6, 2014, as Appl. No. 14/174,827.
Claims priority of provisional application 61/761,504, filed on Feb. 6, 2013.
Prior Publication US 2014/0228660 A1, Aug. 14, 2014
Int. Cl. A61B 5/00 (2006.01); A61B 5/1473 (2006.01); A61B 5/145 (2006.01); A61B 5/1486 (2006.01)
CPC A61B 5/0026 (2013.01) [A61B 5/0031 (2013.01); A61B 5/1473 (2013.01); A61B 5/14532 (2013.01); A61B 5/14865 (2013.01); A61B 2560/0219 (2013.01); A61B 2562/028 (2013.01); A61B 2562/0209 (2013.01); A61B 2562/04 (2013.01); A61B 2562/125 (2013.01)] 15 Claims
OG exemplary drawing
 
1. An implantable device comprising:
a communication system;
a sensor; and
a monolithic substrate comprising an integrated sensor circuit configured to process input from the sensor into a form conveyable by the communication system, and an integrated power supply configured to receive energy from an external source,
wherein:
the communication system is located on a first face of the monolithic substrate and the sensor is located on a second face of the monolithic substrate, the first face being on an opposite side of the monolithic substrate from the second face,
the monolithic substrate comprises a plurality of holes configured to allow fluid flow from the first face of the monolithic substrate to the second face of the monolithic substrate after implantation of the implantable device,
the sensor comprises at least one working electrode, at least one reference electrode, and at least one counter electrode,
the at least one working electrode, the at least one reference electrode, and the at least one counter electrode are high surface area electrodes, each comprising pillars,
the sensor is an integrated sensor and the monolithic substrate further comprises the integrated sensor, and
the communication system comprises a laser.