CPC G01N 33/6893 (2013.01) [G01N 33/563 (2013.01); G01N 2333/705 (2013.01)] | 5 Claims |
1. A method of diagnosing and treating endometriosis in a female subject, the method comprising:
a) detecting levels of soluble and cellular CD200L in a menstrual secretory phase biological sample from the subject, wherein CD200L is detected using an antibody that binds to an exon region of exon 2 of CD200L that does not detect CD200S;
b) comparing the level of CD200L in the biological sample with the level of CD200L in a control;
c) diagnosing the subject with endometriosis when the level of CD200L in the biological sample is higher than the level of CD200L in the control; and
d) treating the subject determined to have endometriosis with a treatment selected from administration of a nonsteroidal anti-inflammatory drug, an opioid, a hormone treatment that slows endometrial tissue growth and prevents new implants of endometrial tissue, gonadotropin-releasing hormone (GnRH) agonist, and a compound that inhibits the interaction of CD200L with CD200RI, and/or a compound that inhibits CD200S.
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