US 11,719,707 B2
Methods for the diagnosis and treatment of endometriosis
David Alexander Clark, Burlington (CA); and Warren George Foster, Ancaster (CA)
Assigned to McMaster University, Hamilton (CA)
Filed by McMaster University, Hamilton (CA)
Filed on Apr. 30, 2020, as Appl. No. 16/863,023.
Application 16/863,023 is a continuation in part of application No. PCT/CA2018/051378, filed on Oct. 30, 2018.
Claims priority of provisional application 62/598,529, filed on Dec. 14, 2017.
Claims priority of provisional application 62/578,785, filed on Oct. 30, 2017.
Prior Publication US 2020/0363429 A1, Nov. 19, 2020
Int. Cl. G01N 33/68 (2006.01); G01N 33/563 (2006.01)
CPC G01N 33/6893 (2013.01) [G01N 33/563 (2013.01); G01N 2333/705 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A method of diagnosing and treating endometriosis in a female subject, the method comprising:
a) detecting levels of soluble and cellular CD200L in a menstrual secretory phase biological sample from the subject, wherein CD200L is detected using an antibody that binds to an exon region of exon 2 of CD200L that does not detect CD200S;
b) comparing the level of CD200L in the biological sample with the level of CD200L in a control;
c) diagnosing the subject with endometriosis when the level of CD200L in the biological sample is higher than the level of CD200L in the control; and
d) treating the subject determined to have endometriosis with a treatment selected from administration of a nonsteroidal anti-inflammatory drug, an opioid, a hormone treatment that slows endometrial tissue growth and prevents new implants of endometrial tissue, gonadotropin-releasing hormone (GnRH) agonist, and a compound that inhibits the interaction of CD200L with CD200RI, and/or a compound that inhibits CD200S.