US 11,719,667 B2
Electrochemical detector
A. L. Roy Vellaisamy, Kowloon (HK); Chi Kong Terrence Lau, Kowloon Tong (HK); and Lin Oo Saw, Kowloon Tong (HK)
Assigned to City University of Hong Kong, Kowloon (HK)
Filed by City University of Hong Kong, Kowloon (HK)
Filed on Oct. 30, 2019, as Appl. No. 16/668,194.
Prior Publication US 2021/0131995 A1, May 6, 2021
Int. Cl. G01N 27/31 (2006.01); G01N 33/574 (2006.01); B01L 3/00 (2006.01)
CPC G01N 27/31 (2013.01) [B01L 3/502707 (2013.01); G01N 33/57446 (2013.01); G01N 33/57492 (2013.01)] 15 Claims
OG exemplary drawing
 
1. An electrochemical detector comprising:
a solution chamber including a first portion and a second portion detachably connected with each other, the first and the second portions each has a compartment for containing a solution,
a pore and an opening is provided with the first portion, the pore and the opening are opened to the compartment of the first portion; the pore and the opening are physically separated from one another;
a pore and an opening is provided with the second portion, the pore and the opening are opened to the compartment in the second portion; the pore and the opening are physically separated from one another;
a pair of electrodes, one being inserted into the compartment of the first portion and the other being inserted into the compartment of the second portion via the respective pores, wherein the pair of electrodes is arranged to form a conductive path when in contact with the solutions retained in the compartments; and;
wherein a substance selection membrane comprises a porous gold deposited track-etched polycarbonate membrane having a pore size of about 50 nm, the membrane is functionalized thereon with a plurality of oligo-RNA receptors for binding with a gastric cancer antigen CA72-4 in the solution, thereby altering current flow in the conductive path; wherein the openings of both compartments are covered by the same substance selection membrane when the first and second portions are in connection with each other.