US 11,719,624 B2
Liquid immersion micro-channel measurement device and measurement method which are based on trapezoidal incident structure prism incident-type silicon
Hyun Mo Cho, Daejeon (KR); Yong Jai Cho, Daejeon (KR); and Won Chegal, Daejeon (KR)
Assigned to KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE, Daejeon (KR)
Appl. No. 16/464,792
Filed by KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE, Daejeon (KR)
PCT Filed Dec. 15, 2016, PCT No. PCT/KR2016/014720
§ 371(c)(1), (2) Date May 29, 2019,
PCT Pub. No. WO2018/101528, PCT Pub. Date Jun. 7, 2018.
Claims priority of application No. 10-2016-0161948 (KR), filed on Nov. 30, 2016.
Prior Publication US 2019/0346363 A1, Nov. 14, 2019
Int. Cl. G01N 21/05 (2006.01); B01L 3/00 (2006.01); G01N 21/21 (2006.01); G01N 33/543 (2006.01); G01N 21/03 (2006.01)
CPC G01N 21/05 (2013.01) [B01L 3/502715 (2013.01); G01N 21/21 (2013.01); G01N 33/54366 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/0663 (2013.01); G01N 21/211 (2013.01); G01N 2021/0378 (2013.01); G01N 2021/052 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A liquid immersion micro-channel measurement device based on trapezoidal incident structure prism incident-type silicon, the liquid immersion micro-channel measurement device comprising:
a micro-channel structure including a support and at least one micro-channel which is formed on the support and has a sample detecting layer to which a first bioadhesive material is fixed to detect a first sample;
a trapezoidal incident structure prism on an upper portion of the micro-channel structure;
a sample injecting unit which injects a buffer solution including a first sample into the at least one micro-channel;
a polarized light generating unit which irradiates incident light polarized through the trapezoidal incident structure prism onto the at least one micro-channel at an incident angle which satisfies a p-wave non-reflection condition; and
a polarized light detecting unit which detects a polarization change of first reflected light reflected from the sample detecting layer, among polarized incident light;
wherein the trapezoidal incident structure prism totally reflects, from a planarized upper interface of the trapezoidal incident structure prism, second reflected light which is reflected from an interface of a lower interface of the trapezoidal incident structure prism and a buffer solution injected into the at least one micro-channel, among polarized incident light which is incident onto the trapezoidal incident structure prism.