US 11,718,831 B2
Reagent for differentiating somatic cells into alveolar epithelial cells, and use of said reagent
Makoto Ishii, Tokyo (JP); Tomoko Betsuyaku, Tokyo (JP); Minoru Ko, Tokyo (JP); Masaki Ieda, Tokyo (JP); Masaya Yotsukura, Tokyo (JP); Hisao Asamura, Tokyo (JP); Ahmed Hegab, Tokyo (JP); Yuhki Nakatake, Tokyo (JP); and Mayumi Oda, Tokyo (JP)
Assigned to KEIO UNIVERSITY, Tokyo (JP)
Appl. No. 16/606,294
Filed by KEIO UNIVERSITY, Tokyo (JP)
PCT Filed Apr. 19, 2018, PCT No. PCT/JP2018/016126
§ 371(c)(1), (2) Date Jan. 28, 2020,
PCT Pub. No. WO2018/194124, PCT Pub. Date Oct. 25, 2018.
Claims priority of application No. 2017-083814 (JP), filed on Apr. 20, 2017.
Prior Publication US 2020/0318074 A1, Oct. 8, 2020
Int. Cl. C12N 5/02 (2006.01); C12N 15/79 (2006.01); C12N 15/63 (2006.01); C07H 21/04 (2006.01); C12N 5/071 (2010.01); A61P 11/00 (2006.01); A61P 31/16 (2006.01); A61K 35/42 (2015.01); C12N 15/86 (2006.01)
CPC C12N 5/0688 (2013.01) [A61K 35/42 (2013.01); A61P 11/00 (2018.01); A61P 31/16 (2018.01); C12N 15/86 (2013.01); C12N 2501/10 (2013.01); C12N 2501/999 (2013.01); C12N 2510/00 (2013.01); C12N 2513/00 (2013.01); C12N 2740/10043 (2013.01)] 8 Claims
 
1. A kit for differentiating somatic cells into alveolar epithelial cells, the kit comprising:
an expression vector including an NK2 homeobox family gene;
an expression vector including a Forkhead box (Fox) family gene, and
an expression vector including a Gata family gene,
wherein the Gata family gene is a Gata Binding Protein 6 (Gata6) gene.