US 11,718,650 B2
Immunogenic peptides and their use in immune disorders
Jean-Marie Saint-Remy, Grez-Doiceau (BE)
Assigned to IMCYSE SA, Liège (BE)
Filed by IMCYSE SA, Liege (BE)
Filed on Apr. 14, 2020, as Appl. No. 16/848,086.
Application 16/848,086 is a division of application No. 14/976,259, filed on Dec. 21, 2015, granted, now 10,662,232.
Application 14/976,259 is a division of application No. 12/377,048, granted, now 9,249,202, issued on Feb. 2, 2016, previously published as PCT/EP2007/007165, filed on Aug. 13, 2007.
Claims priority of application No. 0615966 (GB), filed on Aug. 11, 2006; application No. 0710081 (GB), filed on May 25, 2007; and application No. 0711403 (GB), filed on Jun. 13, 2007.
Prior Publication US 2020/0317742 A1, Oct. 8, 2020
Int. Cl. A61K 35/17 (2015.01); C07K 14/47 (2006.01); C07K 14/435 (2006.01); A61K 39/00 (2006.01); A61K 39/35 (2006.01); C07K 14/415 (2006.01); C07K 14/62 (2006.01); C12N 9/08 (2006.01); C12N 9/88 (2006.01)
CPC C07K 14/4713 (2013.01) [A61K 35/17 (2013.01); A61K 39/0008 (2013.01); A61K 39/35 (2013.01); C07K 14/415 (2013.01); C07K 14/43531 (2013.01); C07K 14/47 (2013.01); C07K 14/4717 (2013.01); C07K 14/62 (2013.01); C12N 9/0065 (2013.01); C12N 9/88 (2013.01); A61K 2039/572 (2013.01); C07K 2319/00 (2013.01); C12Y 111/01008 (2013.01); C12Y 401/01015 (2013.01)] 8 Claims
 
1. A method for treating an allergic condition in an individual, comprising administering to said individual an isolated immunogenic peptide with a length of at most 75 amino acids, wherein said immunogenic peptide comprises:
a T cell epitope sequence of an antigenic protein, wherein said antigenic protein is an allergen and wherein said T cell epitope sequence is an epitope sequence recognized by WIC class II molecules, and
a [CST]-(X)2-C or C-X(2)-[CST] thioredox sequence motif wherein X is any amino acid,
said thioredox sequence motif being either adjacent to said epitope sequence, or separated from said epitope sequence by a linker of at most 7 amino acids, wherein said thioredox sequence motif does not naturally occur within a region of 11 amino acids N-terminally or C-terminally of the T cell epitope sequence in said antigenic protein.