US 11,718,625 B2
Near-infrared fluorescent molecule active targeting folate receptor and preparation method thereof
Huiming Cai, Jiangsu (CN); and Yiqing Wang, Jiangsu (CN)
Assigned to NANJING UOYUAN MEDICAL DEVICES CO., LTD, Jiangsu (CN)
Appl. No. 17/596,423
Filed by NANJING NUOYUAN MEDICAL DEVICES CO., LTD, Jiangsu (CN)
PCT Filed Nov. 27, 2020, PCT No. PCT/CN2020/132366
§ 371(c)(1), (2) Date Dec. 9, 2021,
PCT Pub. No. WO2022/082932, PCT Pub. Date Apr. 28, 2022.
Claims priority of application No. 202011145658.3 (CN), filed on Oct. 23, 2020.
Prior Publication US 2022/0267330 A1, Aug. 25, 2022
Int. Cl. C07D 487/04 (2006.01); A61K 49/00 (2006.01); C09K 11/06 (2006.01); G01N 21/64 (2006.01)
CPC C07D 487/04 (2013.01) [A61K 49/0021 (2013.01); C09K 11/06 (2013.01); G01N 21/6458 (2013.01); C09K 2211/1029 (2013.01); C09K 2211/1059 (2013.01)] 3 Claims
 
1. A near-infrared fluorescent molecule active targeting a folate receptor, with a structural formula as follows:

OG Complex Work Unit Chemistry
wherein M is independently selected from the group consisting of H, Na, and K.