CPC C07D 471/04 (2013.01) [A61P 35/00 (2018.01); A61P 35/02 (2018.01)] | 16 Claims |
1. A compound, or a pharmaceutically acceptable salt thereof, having Formula I-A:
wherein:
A is selected from the group consisting of:
E is a carbon atom and the depicted dashed bond forms a double bond; or
E is a —C(H)— and the depicted dashed bond is absent to form a single bond; or
E is a nitrogen atom and the depicted dashed bond is absent to form a single bond;
X1, X2, and X3 are each —CR8═, or one of X1, X2, and X3 is —N═ and two X1, X2, and X3 are each —CR8;
R1a and R1b taken together with the carbon atom to which they are attached form
R2 is selected from the group consisting of —NO2, —SO2CH3, and —SO2CF3;
R3 is selected from the group consisting of hydrogen, —CN, —C≡CH, and —N(R4a)(R4b);
R2a is selected from the group consisting of hydrogen and halogen;
R4a is selected from the group consisting of optionally substituted C1-6 alkyl, optionally substituted C3-6 cycloalkyl, optionally substituted heterocyclo, optionally substitute heteroalkyl, optionally substituted (cycloalkyl)alkyl, and optionally substituted (heterocyclo)alkyl;
R4b is selected from the group consisting of hydrogen and C1-4 alkyl;
R5 is selected from the group consisting of is selected from the group consisting of optionally substituted C1-6 alkyl, optionally substituted heterocyclo, optionally substituted heteroalkyl, optionally substituted (cycloalkyl)alkyl, and optionally substituted (heterocyclo)alkyl;
R6a, R6c, R6e, R6f, and R6g are each independently selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, optionally substituted C3-6 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclo, optionally substituted heteroalkyl, optionally substituted (cycloalkyl)alkyl, and optionally substituted (heterocyclo)alkyl;
R6b and R6d are each independently selected from the group consisting of hydrogen, C1-4 alkyl, and halogen;
R7 is selected from the group consisting of optionally substituted C1-6 alkyl, optionally substituted heterocyclo, optionally substituted heteroalkyl, optionally substituted (cycloalkyl)alkyl, and optionally substituted (heterocyclo)alkyl; and
R8 is selected from the group consisting of hydrogen and halogen.
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