CPC C07D 417/14 (2013.01) [A61P 35/00 (2018.01); C07B 2200/05 (2013.01)] | 20 Claims |
1. A compound represented by formula (II) or a pharmaceutically acceptable salt thereof,
wherein,
T1 is CH or N;
n is 1 or 2;
R1 and R2 are each independently H, D, F, Cl or C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br and I;
or R1 and R2 combining with the carbon atoms to which they are attached form
R3 and R4 are each independently H or C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I and —OH;
R5 and P6 are each independently H or C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I, —OH and —OCH3;
R7 is phenyl or pyridyl, wherein the phenyl and pyridyl are optionally substituted by 1, 2, 3 or 4 Ra;
R8 is H, F, Cl or Br;
R9 is tetrahydro-2H-pyranyl, wherein the tetrahydro-2H-pyranyl is optionally substituted by 1, 2, 3 or 4 Rb;
Ra is each independently F, Cl, Br, I, C1-3 alkyl, C1-3 alkoxy, NH—C1-3 alkyl or N—(C1-3 alkyl)2, wherein the C1-3 alkyl, C1-3 alkoxy, —NH—C1-3 alkyl and —N—(C1-3 alkyl)2 are each independently and optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I and —OH;
Rb is each independently F, Cl, Br, I, D or C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I and —OH.
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