US 11,718,610 B2
Compounds containing benzosultam
Xile Liu, Shanghai (CN); Charles Z. Ding, Shanghai (CN); Shuhui Chen, Shanghai (CN); Lihong Hu, Shanghai (CN); Haiwen Wan, Shanghai (CN); and Xiu Jiang, Shanghai (CN)
Assigned to MEDSHINE DISCOVERY INC., Nanjing (CN)
Appl. No. 17/922,195
Filed by MEDSHINE DISCOVERY INC., Nanjing (CN)
PCT Filed Apr. 26, 2021, PCT No. PCT/CN2021/089889
§ 371(c)(1), (2) Date Oct. 28, 2022,
PCT Pub. No. WO2021/218912, PCT Pub. Date Nov. 4, 2021.
Claims priority of application No. 202010363156.1 (CN), filed on Apr. 30, 2020; and application No. 202110145140.8 (CN), filed on Feb. 2, 2021.
Prior Publication US 2023/0183230 A1, Jun. 15, 2023
Int. Cl. C07D 417/14 (2006.01); A61P 35/00 (2006.01)
CPC C07D 417/14 (2013.01) [A61P 35/00 (2018.01); C07B 2200/05 (2013.01)] 20 Claims
 
1. A compound represented by formula (II) or a pharmaceutically acceptable salt thereof,

OG Complex Work Unit Chemistry
wherein,
T1 is CH or N;
n is 1 or 2;
R1 and R2 are each independently H, D, F, Cl or C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br and I;
or R1 and R2 combining with the carbon atoms to which they are attached form

OG Complex Work Unit Chemistry
R3 and R4 are each independently H or C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I and —OH;
R5 and P6 are each independently H or C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I, —OH and —OCH3;
R7 is phenyl or pyridyl, wherein the phenyl and pyridyl are optionally substituted by 1, 2, 3 or 4 Ra;
R8 is H, F, Cl or Br;
R9 is tetrahydro-2H-pyranyl, wherein the tetrahydro-2H-pyranyl is optionally substituted by 1, 2, 3 or 4 Rb;
Ra is each independently F, Cl, Br, I, C1-3 alkyl, C1-3 alkoxy, NH—C1-3 alkyl or N—(C1-3 alkyl)2, wherein the C1-3 alkyl, C1-3 alkoxy, —NH—C1-3 alkyl and —N—(C1-3 alkyl)2 are each independently and optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I and —OH;
Rb is each independently F, Cl, Br, I, D or C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I and —OH.