CPC C07D 403/12 (2013.01) [A61P 35/00 (2018.01); C07D 413/12 (2013.01); C07B 2200/07 (2013.01)] | 21 Claims |
1. A compound of Formula (I):
or a pharmaceutically acceptable salt or solvate thereof, wherein:
R1 is -L1-(5-10 membered heteroaryl) or -L1-(C6-C12 aryl), where said 5-10 membered heteroaryl or C6-C12 aryl is optionally substituted by one or more R4;
R2 and R3 are independently H, C1-C6 alkyl, C1-C6 fluoroalkyl, -L2-(C3-C7 cycloalkyl) or -L2-(4-7 membered heterocyclyl), where each said C1-C6 alkyl and C1-C6 fluoroalkyl is optionally substituted by one or more R5 and each said C3-C7 cycloalkyl and 4-7 membered heterocyclyl is optionally substituted by one or more R6; or
R2 and R3 are taken together with the N-atom to which they are attached to form a 4-6 membered heterocyclyl optionally containing an additional heteroatom selected from O, N(R7) and S(O)q as a ring member, where said 4-6 membered heterocyclyl is optionally substituted by one or more R8;
each L1 and L2 is independently a bond or a C1-C2 alkylene optionally substituted by one or more R9;
each R4 is independently F, Cl, OH, CN, NR10R11, C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 alkoxy, C1-C4 fluoroalkoxy, C3-C8 cycloalkyl, C(O)NR10R11, SO2R12, SO(═NH)R12 or SO2NR10R11; where each C1-C4 alkyl and C1-C4 fluoroalkyl is optionally substituted by one or more R13;
each R5 is independently OH, C1-C4 alkoxy or NR10R11;
each R6 is independently F, OH, C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 alkoxy, C1-C4 fluoroalkoxy or NR10R11 where each C1-C4 alkyl and C1-C4 fluoroalkyl is optionally substituted by one or more R13;
R7 is H, C1-C4 alkyl or C(O)-C1-C4 alkyl;
each R8 is independently F, OH, C1-C4 alkyl, C1-C4 alkoxy or CN;
each R9 is independently F, OH or C1-C2 alkyl;
each R10 and R11 is independently H or C1-C4 alkyl;
each R12 is C1-C4 alkyl or C3-C6 cycloalkyl;
each R13 is independently OH, C1-C4 alkoxy or NR14R15;
each R14 and R15 is independently H or C1-C4 alkyl; and
q is 0, 1 or 2.
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