US 11,718,596 B2
Amyloid targeting agents and methods of using the same
Jerry Yang, La Jolla, CA (US); Emmanuel A. Theodorakis, San Diego, CA (US); and Stella Sarraf, Beverly Hills, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US); and Amydis, Inc., San Diego, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US); and Amydis, Inc., San Diego, CA (US)
Filed on Feb. 9, 2021, as Appl. No. 17/171,947.
Application 17/171,947 is a continuation of application No. 16/439,505, filed on Jun. 12, 2019, granted, now 10,934,264.
Application 16/439,505 is a continuation of application No. 15/969,328, filed on May 2, 2018, granted, now 10,370,345, issued on Aug. 6, 2019.
Application 15/969,328 is a continuation of application No. 14/915,883, granted, now 10,005,745, issued on Jun. 26, 2018, previously published as PCT/US2015/021512, filed on Mar. 19, 2015.
Claims priority of provisional application 61/955,366, filed on Mar. 19, 2014.
Prior Publication US 2021/0371390 A1, Dec. 2, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 295/155 (2006.01); C07D 211/06 (2006.01); C07D 213/57 (2006.01); C07D 213/85 (2006.01); C07D 241/04 (2006.01); C07D 265/30 (2006.01); C07D 295/04 (2006.01); C07D 307/52 (2006.01); C07D 333/22 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 405/04 (2006.01); C07D 405/10 (2006.01); C07D 407/10 (2006.01); C07D 409/04 (2006.01); C07D 409/10 (2006.01); C07D 409/14 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01); C07D 295/13 (2006.01); A61B 5/00 (2006.01); A61P 25/28 (2006.01); C07C 255/42 (2006.01); C07C 255/58 (2006.01); C07C 255/59 (2006.01); C07C 311/35 (2006.01); C07C 255/43 (2006.01); C07H 13/04 (2006.01); C07H 19/056 (2006.01); C07H 13/00 (2006.01)
CPC C07D 295/155 (2013.01) [A61B 5/0075 (2013.01); A61P 25/28 (2018.01); C07C 255/42 (2013.01); C07C 255/58 (2013.01); C07C 255/59 (2013.01); C07C 311/35 (2013.01); C07D 211/06 (2013.01); C07D 213/57 (2013.01); C07D 213/85 (2013.01); C07D 241/04 (2013.01); C07D 265/30 (2013.01); C07D 295/04 (2013.01); C07D 307/52 (2013.01); C07D 333/22 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 405/04 (2013.01); C07D 405/10 (2013.01); C07D 407/10 (2013.01); C07D 409/04 (2013.01); C07D 409/10 (2013.01); C07D 409/14 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07H 13/04 (2013.01); C07H 19/056 (2013.01); A61B 5/4082 (2013.01); A61B 5/4088 (2013.01)] 20 Claims
 
1. A compound of Formula (Ie):

OG Complex Work Unit Chemistry
wherein
EDG is heterocycloalkyl of no more than 10 carbons optionally substituted with one or more R17;
each R17 is independently halogen, —OR18, —NR19R20, C1-C10 alkyl, or C1-C10 heteroalkyl;
each of R18, R19 and R20 is independently hydrogen, C1-C10 alkyl, C1-C10 heteroalkyl, or cycloalkyl of no more than 10 carbon atoms, each of which except for hydrogen is optionally substituted with one or more R21;
each R21 is independently halogen, —OR22, —NR23R24, C1-C10 alkyl, C1-C10 heteroalkyl, cycloalkyl of no more than 10 carbon atoms, heterocycloalkyl of no more than 10 carbon atoms, aryl of no more than 10 carbon atoms, or heteroaryl of no more than 10 carbon atoms;
each of R22, R23 and R24 is independently hydrogen or C1-C10 alkyl;
Ar is naphthylene optionally substituted with one or more R1; each R1 is independently halogen, —OR2, —NR3R4, C1-C10 alkyl, or C1-C10 heteroalkyl, each of R2, R3 and R4 is independently hydrogen, C1-C10 alkyl, or C1-C10 heteroalkyl;
R84 is hydrogen or optionally substituted C1-C10 alkyl;
EWG is —CN; and
WSG is:

OG Complex Work Unit Chemistry
wherein n is an integer from 2-50, and R81 is hydrogen or C1-C10 alkyl.