CPC C07D 235/18 (2013.01) [C07D 239/74 (2013.01); C07D 241/42 (2013.01); C12N 9/0006 (2013.01); A61K 31/4164 (2013.01); A61K 45/06 (2013.01)] | 7 Claims |
1. A method of inhibiting the activity of 15-PGDH enzyme, the method comprising:
administering to the enzyme a compound having the structure of formula (II), or a pharmaceutically acceptable salt thereof;
wherein
X3 is CR8, the compound forming a polycyclic heteroaryl with 10 ring atoms;
X4 is N, NH, or CR7;
X5 is N, C═O, or CR16, wherein:
X5 is N if X4 is CR7;
X4 is NH if X5 is C═O;
X5 is CR16 if X4 is N and X3 is CR8;
R9, R10, and R16 are the same or different and are independently selected from the group consisting of hydrogen, oxygen, substituted or unsubstituted C1-C24 alkyl, C2-C24 alkenyl, C2-C24 alkynyl, C5-C20 aryl, heterocycloalkenyl containing from 5-7 ring atoms, heteroaryl or heterocyclyl containing from 5-14 ring atoms, C6-C24 alkaryl, C6-C24 aralkyl, halo, silyl, hydroxyl, sulfhydryl, C1-C24 alkoxy, C2-C24 alkenyloxy, C2-C24 alkynyloxy, C5-C20 aryloxy, acyl, acyloxy, C2-C24 alkoxycarbonyl, C6-C20 aryloxycarbonyl, C2-C24 alkylcarbonato, C6-C20 arylcarbonato, carboxy, carboxylato, carbamoyl, C1-C24 alkyl-carbamoyl, arylcarbamoyl, thiocarbamoyl, carbamido, cyano, isocyano, cyanato, isocyanato, isothiocyanato, azido, formyl, thioformyl, amino, C1-C24 alkyl amino, C5-C20 aryl amino, C2-C24 alkylamido, C6-C20 arylamido, sulfanamido, imino, alkylimino, arylimino, nitro, nitroso, sulfo, sulfonato, C1-C24 alkylsulfanyl, arylsulfanyl, C1-C24 alkylsulfinyl, C5-C20 arylsulfinyl, C1-C24 alkylsulfonyl, C5-C20 arylsulfonyl, sulfonamide, phosphono, phosphonato, phosphinato, phospho, phosphino, polyalkyl ethers, phosphates, phosphate esters, and combinations thereof;
R7 and R8 are same or different and are each independently selected from the group consisting of H, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted cycloalkyl, and a substituted or unsubstituted heterocyclyl, and at least one of R7 or R8 is not H; and
wherein the compound of formula (II) is not
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