US 11,718,576 B2
Compositions and methods comprising resveratrol
Joseph D. Ceccoli, Farmingville, NY (US); Brian R. Costello, Port Jefferson Station, NY (US); Michael L. Ingrassia, Hauppauge, NY (US); Christopher M. Judd, Riverhead, NY (US); and Maciej Bernard Szczepanik, Mount Sinai, NY (US)
Assigned to Biocogent, LLC, Stony Brook, NY (US)
Filed by Biocogent, LLC, Stony Brook, NY (US)
Filed on Apr. 11, 2022, as Appl. No. 17/717,952.
Application 17/717,952 is a division of application No. 17/066,075, filed on Oct. 8, 2020, granted, now 11,339,112.
Application 17/066,075 is a division of application No. 16/414,506, filed on May 16, 2019, granted, now 10,836,702, issued on Nov. 17, 2020.
Application 16/414,506 is a division of application No. 15/115,338, granted, now 10,301,248, issued on May 28, 2019, previously published as PCT/US2015/014629, filed on Feb. 5, 2015.
Claims priority of provisional application 62/054,553, filed on Sep. 24, 2014.
Claims priority of provisional application 61/936,490, filed on Feb. 6, 2014.
Prior Publication US 2022/0234984 A1, Jul. 28, 2022
Int. Cl. C07C 67/08 (2006.01); C07C 69/84 (2006.01); A61K 8/37 (2006.01); A61K 31/618 (2006.01); A61Q 19/00 (2006.01)
CPC C07C 67/08 (2013.01) [A61K 8/37 (2013.01); A61K 31/618 (2013.01); A61Q 19/00 (2013.01); C07C 69/84 (2013.01); A61K 2800/10 (2013.01)] 12 Claims
 
1. A method of synthesizing a mixture of resveratrol salicylates, the method comprising the steps of:
(a) activating resveratrol in the presence of a first solvent to produce activated resveratrol;
(b) activating salicylic acid in the presence of a second solvent to produce activated salicylic acid; and
(c) combining the activated resveratrol and the activated salicylic acid to produce the mixture of resveratrol salicylates, the mixture comprising:
a resveratrol substituted with more than three salicylic acids; and
at least one compound selected from the following:
(a) a resveratrol substituted with one salicylic acid,
(b) a resveratrol substituted with two salicylic acids,
(c) a resveratrol substituted with three salicylic acids.