US 11,717,801 B2
Micro-reactor and method of use
Michael Hsiao, Taipei (TW); Ming-Che Hsieh, Taipei (TW); Zhen Bao, Changzhou (CN); Ming-Hsien Chan, Taipei (TW); Ru-Shi Liu, Taipei (TW); An-Bang Wang, Taipei (TW); and Chia-Chih Chu, Taipei (TW)
Assigned to Academia Sinica, Taipei (TW)
Appl. No. 17/625,349
Filed by Academia Sinica, Taipei (TW)
PCT Filed Aug. 5, 2020, PCT No. PCT/US2020/044914
§ 371(c)(1), (2) Date Jan. 7, 2022,
PCT Pub. No. WO2021/026176, PCT Pub. Date Feb. 11, 2021.
Claims priority of provisional application 62/883,106, filed on Aug. 5, 2019.
Prior Publication US 2022/0323925 A1, Oct. 13, 2022
Int. Cl. B01J 19/00 (2006.01)
CPC B01J 19/0093 (2013.01) [B01J 2219/00873 (2013.01); B01J 2219/00957 (2013.01); B01J 2219/00961 (2013.01); B01J 2219/00963 (2013.01); B01J 2219/00972 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A micro-reactor for synthesizing a molecule detectable by its property, comprising,
(a) a processor;
(b) a storage unit coupled to the processor, comprising,
a first container configured to house a first reagent at a first temperature; and
a second container configured to house a second reagent at a second temperature;
(c) a reaction unit coupled to the processor and the storage unit, wherein the reaction unit comprises,
at least one reaction chamber configured to allow the first and second reagents supplied from the storage unit to react at a third temperature and thereby forms a product;
(d) a detector coupled to the processor and the reaction unit for detecting the property of the product; and
(e) a collector disposed downstream to the reaction unit for collecting the product;
wherein,
the storage unit and reaction unit are independently controlled by the process; and
the processor is programmed with instructions to,
control the first and second temperatures of the first and second containers, the third temperature of the reaction chamber, and the volumes and flow rates of the first and second reagents provided from the first and second containers;
execute a process for collecting the product in the collector, based on the property of the product detected by the detector;
when the property of the product matches with the property of the molecule, then collecting the product as the molecule in the collector; or
when the property of the product does not match with the property of the molecule, then adjusting the volumes and/or flow rates of the first and/or second reagents provided to the reaction unit, and/or adjusting the first, second, and/or third temperatures until the property of the product matches with the property of the molecule.