US 11,717,703 B2
Delivery of radiation by column and generating a treatment plan therefor
James Cooley, Littleton, MA (US); and Townsend Zwart, Littleton, MA (US)
Assigned to MEVION MEDICAL SYSTEMS, INC., Littleton, MA (US)
Filed by Mevion Medical Systems, Inc., Littleton, MA (US)
Filed on Apr. 4, 2022, as Appl. No. 17/712,313.
Application 17/712,313 is a continuation of application No. 16/811,130, filed on Mar. 6, 2020, granted, now 11,291,861.
Claims priority of provisional application 62/889,861, filed on Aug. 21, 2019.
Claims priority of provisional application 62/889,825, filed on Aug. 21, 2019.
Claims priority of provisional application 62/853,387, filed on May 28, 2019.
Claims priority of provisional application 62/815,721, filed on Mar. 8, 2019.
Prior Publication US 2022/0296927 A1, Sep. 22, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 5/10 (2006.01)
CPC A61N 5/1045 (2013.01) [A61N 5/1031 (2013.01); A61N 5/1043 (2013.01); A61N 5/1065 (2013.01); A61N 5/1079 (2013.01); A61N 2005/1087 (2013.01)] 31 Claims
OG exemplary drawing
 
1. One or more non-transitory machine-readable storage media storing instructions that are executable to implement a treatment planning system for a particle therapy system, the treatment planning system comprising:
a prediction model that characterizes the particle therapy system and a patient to be treated by the particle therapy system, the prediction model characterizing the particle therapy system at least in part by characterizing a timing at which the particle therapy system can deliver radiation;
a relative biological effectiveness (RBE) model that characterizes a relative biological effectiveness of the radiation on tissue based on the timing of delivery of the radiation; and
a dose calculation engine to determine a dose regimen for delivery of the radiation to voxels of the patient, the dose calculation engine being configured to determine the dose regimen based on the prediction model and the RBE model.