US 11,717,661 B2
Methods and systems for ultrasound assisted delivery of a medicant to tissue
Michael H. Slayton, Tempe, AZ (US)
Assigned to Guided Therapy Systems, LLC, Scottsdale, AZ (US)
Appl. No. 15/555,913
Filed by Guided Therapy Systems, LLC, Mesa, AZ (US)
PCT Filed Mar. 3, 2016, PCT No. PCT/US2016/020600
§ 371(c)(1), (2) Date Sep. 5, 2017,
PCT Pub. No. WO2016/141136, PCT Pub. Date Sep. 9, 2016.
Application 15/555,913 is a continuation of application No. 14/637,237, filed on Mar. 3, 2015, abandoned.
Claims priority of provisional application 62/127,720, filed on Mar. 3, 2015.
Claims priority of provisional application 62/127,715, filed on Mar. 3, 2015.
Prior Publication US 2018/0043147 A1, Feb. 15, 2018
Int. Cl. A61M 37/00 (2006.01); A61N 7/00 (2006.01); A61B 90/00 (2016.01)
CPC A61M 37/0092 (2013.01) [A61B 2090/378 (2016.02); A61M 2037/0007 (2013.01); A61N 7/00 (2013.01); A61N 2007/0008 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A method for ultrasound-assisted delivery of a medicant through a stratum corneum layer of a skin surface, the method comprising:
a) administering the medicant and an anesthetic to the skin surface;
b) coupling an ultrasound transducer to the medicant, the anesthetic, and the skin surface; and
c) generating inertial cavitation in the stratum corneum layer and driving the medicant through the stratum corneum layer by applying a first pulsed acoustic energy field from the ultrasound transducer to the skin surface, the first pulsed acoustic energy field having a frequency from 1 MHz to 30 MHz, a peak intensity from 100 W/cm2 to 100 kW/cm2 at the skin surface, and a pulse width from 33 nanoseconds to 5 seconds, wherein the inertial cavitation initiates damage in or beneath the skin surface, the anesthetic alleviating pain or swelling associated with the damage in or beneath the skin surface.