US 11,717,639 B2
Combinatorial therapeutic systems and methods
Tassilo Baeuerle, Sunnyvale, CA (US); and Harald F. Stock, Sunnyvale, CA (US)
Assigned to COGNIFISENSE, INC., Sunnyvale, CA (US)
Appl. No. 16/965,203
Filed by Cognifisense, Inc., Sunnyvale, CA (US)
PCT Filed Jan. 25, 2019, PCT No. PCT/US2019/015301
§ 371(c)(1), (2) Date Jul. 27, 2020,
PCT Pub. No. WO2019/148047, PCT Pub. Date Aug. 1, 2019.
Claims priority of provisional application 62/654,945, filed on Apr. 9, 2018.
Claims priority of provisional application 62/642,726, filed on Mar. 14, 2018.
Claims priority of provisional application 62/621,793, filed on Jan. 25, 2018.
Prior Publication US 2021/0060290 A1, Mar. 4, 2021
Int. Cl. A61M 21/02 (2006.01); A61P 25/04 (2006.01); A61K 31/137 (2006.01); A61K 38/07 (2006.01); A61M 21/00 (2006.01)
CPC A61M 21/02 (2013.01) [A61K 31/137 (2013.01); A61K 38/07 (2013.01); A61P 25/04 (2018.01); A61M 2021/005 (2013.01); A61M 2021/0016 (2013.01); A61M 2021/0022 (2013.01); A61M 2021/0027 (2013.01); A61M 2021/0077 (2013.01); A61M 2205/3553 (2013.01); A61M 2205/507 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A combinatorial therapeutic system for treating and/or mitigating pain, comprising:
a therapeutically effective amount of an analgesic selected from tapentadol or difelikefalin (CR845); and
a computer system that includes at least one processor, computer-readable memory, and an output device, the computer system configured to provide an artificial sensory experience comprising one or more of a 2D artificial sensory experience, a 3D artificial sensory experience, a 4D artificial sensory experience, holography, augmented reality, virtual reality, or mixed reality,
wherein the output device is configured to produce, during the artificial sensory experience, sensory stimuli comprising a virtual representation of a patient's symptom that is perceptible to the patient, wherein the symptom includes pain, and
wherein the computer system is configured to cause the virtual representation of the patient's pain to perceptibly change during the artificial sensory experience.