US 11,717,596 B2
Methods and compositions for repair of cartilage using an in vivo bioreactor
Lionel C. Sevrain, West Palm Beach, FL (US); and Sylvie Y. Verdier-Sevrain, West Palm Beach, FL (US)
Assigned to SpinalCyte, LLC, Houston, TX (US)
Filed by SpinalCyte, LLC, Houston, TX (US)
Filed on May 4, 2020, as Appl. No. 16/865,926.
Application 12/775,736 is a division of application No. 11/671,082, filed on Feb. 5, 2007, granted, now 7,850,983, issued on Dec. 14, 2020.
Application 16/865,926 is a continuation of application No. 16/038,915, filed on Jul. 18, 2018, granted, now 10,806,824.
Application 16/038,915 is a continuation of application No. 15/371,994, filed on Dec. 7, 2016, granted, now 10,052,410, issued on Aug. 21, 2018.
Application 15/371,994 is a continuation of application No. 12/775,736, filed on May 7, 2010, granted, now 9,545,432, issued on Jan. 17, 2017.
Claims priority of provisional application 60/785,478, filed on Mar. 24, 2006.
Claims priority of provisional application 60/771,172, filed on Feb. 7, 2006.
Prior Publication US 2020/0261620 A1, Aug. 20, 2020
Int. Cl. A61L 27/38 (2006.01); A61K 45/06 (2006.01); A61K 35/32 (2015.01); A61K 35/33 (2015.01); C12N 5/077 (2010.01); A61F 2/30 (2006.01); A61F 2/44 (2006.01); A61K 38/18 (2006.01); A61F 2/32 (2006.01); A61F 2/38 (2006.01); A61F 2/40 (2006.01); A61F 2/28 (2006.01); A61F 2/46 (2006.01)
CPC A61L 27/3817 (2013.01) [A61F 2/30756 (2013.01); A61F 2/441 (2013.01); A61K 35/32 (2013.01); A61K 35/33 (2013.01); A61K 38/18 (2013.01); A61K 45/06 (2013.01); A61L 27/3852 (2013.01); A61L 27/3895 (2013.01); C12N 5/0655 (2013.01); A61F 2/3099 (2013.01); A61F 2/32 (2013.01); A61F 2/38 (2013.01); A61F 2/3804 (2013.01); A61F 2/40 (2013.01); A61F 2002/286 (2013.01); A61F 2002/2817 (2013.01); A61F 2002/30062 (2013.01); A61F 2002/30586 (2013.01); A61F 2002/30677 (2013.01); A61F 2002/30762 (2013.01); A61F 2002/30764 (2013.01); A61F 2002/30766 (2013.01); A61F 2002/444 (2013.01); A61F 2002/445 (2013.01); A61F 2002/4445 (2013.01); A61F 2002/4635 (2013.01); A61F 2210/0004 (2013.01); A61L 2430/06 (2013.01); C12N 2500/02 (2013.01); C12N 2500/38 (2013.01); C12N 2501/155 (2013.01); C12N 2506/1307 (2013.01); C12N 2521/00 (2013.01); C12N 2533/74 (2013.01)] 5 Claims
 
1. A composition comprising chondrocyte-like cells derived from fibroblasts, wherein said chondrocyte-like cells produce Sox-9 protein and one or more of aggrecan, type II collagen, cartilage link protein, perlecan, and sulfated proteoglycan.