US 11,717,594 B2
Antimicrobial medical biomaterial and a method for preparing the same
Qing Liu, Beijing (CN)
Assigned to B. J. ZH. F. PANTHER MEDICAL EQUIPMENT CO., LTD., Beijing (CN)
Filed by B. J. ZH. F. Panther Medical Equipment Co., Ltd., Beijing (CN)
Filed on Feb. 8, 2021, as Appl. No. 17/170,013.
Claims priority of application No. 202010292857.0 (CN), filed on Apr. 15, 2020.
Prior Publication US 2021/0322639 A1, Oct. 21, 2021
Int. Cl. A61L 27/36 (2006.01); A61L 24/00 (2006.01); A61L 15/44 (2006.01); A61K 33/38 (2006.01); A61L 15/20 (2006.01); A61L 27/54 (2006.01); A61L 15/40 (2006.01); A61L 27/52 (2006.01)
CPC A61L 27/3629 (2013.01) [A61K 33/38 (2013.01); A61L 15/20 (2013.01); A61L 15/40 (2013.01); A61L 15/44 (2013.01); A61L 24/0005 (2013.01); A61L 24/0015 (2013.01); A61L 27/3687 (2013.01); A61L 27/3691 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 2300/104 (2013.01); A61L 2300/216 (2013.01); A61L 2300/404 (2013.01); A61L 2430/34 (2013.01)] 7 Claims
 
1. A method for preparing an antibacterial medical biomaterial, comprising:
a) placing an acellular small intestinal submucosal matrix material in a sodium hydroxide solution containing sulfadiazine, and controlling pH of the solution between 7.1 and 13.0, so as to obtain an intermediate material loaded with sulfadiazine sodium on the surface and/or inside thereof;
b) after removing the intermediate material obtained in step a from the solution, washing the same with a sodium chloride solution, and then performing a drying treatment, soaking the intermediate material in a silver nitrate solution, and substituting sodium ions on a sulfadiazine sodium pyrimidine with silver ions in the silver nitrate to obtain an acellular small intestinal submucosal matrix material loaded with sulfadiazine silver;
c) performing a surface plasma treatment on the acellular small intestinal submucosal matrix material loaded with sulfadiazine silver obtained in step b to hydroxylate a surface of the acellular small intestinal submucosal matrix material;
d) coating a layer of antibacterial gel layer on the surface of the acellular small intestinal submucosal matrix material in step c, wherein the antibacterial gel layer and the acellular small intestinal submucosal matrix material are combined by hydrogen bonding;
e) after absorbable fibers are subjected to plasma treatment, preparing the absorbable fiber solution or gel liquid, and then stirring the sulfadiazine silver and the absorbable fiber solution or gel liquid uniformly to obtain a mixed solution or a mixed gel liquid;
f) coating the mixed solution or mixed gel liquid in step e on the surface of the acellular small intestinal submucosal matrix material with the antibacterial gel layer prepared in step d, and placing the acellular small intestinal submucosal matrix material in an oven or freeze-drying to obtain an antibacterial medical biomaterial.