CPC A61L 2/18 (2013.01) [A61L 2/28 (2013.01); B01D 15/20 (2013.01); B01D 15/3809 (2013.01); G01N 30/50 (2013.01); G01N 2030/8831 (2013.01)] | 14 Claims |
1. A method for microbial bioburden reduction of a chromatography matrix, comprising: contacting a chromatography matrix with a composition comprising from about 0.1 M to about 0.5 M acetic acid, wherein the contacting step is performed for about 1 hour to about 4 hours, wherein the composition does not comprise an alcohol, guanidine hydrochloride, or urea, and the method does not comprise a step of contacting the chromatography matrix with a sodium hydroxide solution.
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