US 11,717,580 B2
Cyclodextrin-linked polyvalent ligands for complexation of metal ions
Chang-Chun Ling, Calgary (CA); Pier-Luc Champagne, Calgary (CA); Ping Zhang, Calgary (CA); and Géraldine Gouhier, Mount Saint Aignan (FR)
Appl. No. 17/53,146
Filed by UTI LIMITED PARTNERSHIP, Calgary (CA); and CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR)
PCT Filed May 7, 2019, PCT No. PCT/CA2019/050603
§ 371(c)(1), (2) Date Nov. 5, 2020,
PCT Pub. No. WO2019/213756, PCT Pub. Date Nov. 14, 2019.
Claims priority of provisional application 62/667,954, filed on May 7, 2018.
Prior Publication US 2021/0236661 A1, Aug. 5, 2021
Int. Cl. A61K 49/12 (2006.01); A61K 49/08 (2006.01); C02F 101/20 (2006.01); C02F 1/68 (2023.01); C02F 101/00 (2006.01)
CPC A61K 49/124 (2013.01) [A61K 49/085 (2013.01); A61K 49/122 (2013.01); C02F 1/683 (2013.01); C02F 2101/006 (2013.01); C02F 2101/20 (2013.01)] 20 Claims
 
1. A compound of formula Mz(L), wherein:
M is a metal ion;
L is a ligand of formula I
A-[W—X—Y—N(CH2COOH)2]n  (formula I);
and
z is an integer of 1 to 4,
wherein, with reference to formula I,
A is cyclodextrin or a derivative thereof, a disaccharide, starch or other carbohydrate polymer;
W is a chemical bond, or a linker comprising a substituted or unsubstituted C1-C5 carbon chain;
X is a five or six membered ring having one or more heteroatoms;
Y is a linker comprising a substituted or unsubstituted C1-C3 carbon chain; and
n is an integer of 2 to 8.