US 11,717,570 B2
Gas-filled microvesicles
Philippe Bussat, Pers-Jussy (FR); Samir Cherkaoui, Feigeres (FR); David Lazarus, Saint-Julien-en-Genevois (FR); Eric Allémann, Troinex (CH); Michel Schneider, Troinex (CH); and Christian Guillot, Beaumont (FR)
Assigned to Bracco Suisse SA, Cadempino (CH)
Appl. No. 17/610,853
Filed by Bracco Suisse SA, Cadempino (CH)
PCT Filed May 14, 2020, PCT No. PCT/EP2020/063560
§ 371(c)(1), (2) Date Nov. 12, 2021,
PCT Pub. No. WO2020/229643, PCT Pub. Date Nov. 19, 2020.
Application 17/610,853 is a continuation in part of application No. 16/788,083, filed on Feb. 11, 2020, abandoned.
Application 16/788,083 is a continuation in part of application No. 16/688,540, filed on Nov. 19, 2019, abandoned.
Application 16/688,540 is a continuation in part of application No. 16/413,526, filed on May 15, 2019, abandoned.
Prior Publication US 2022/0211850 A1, Jul. 7, 2022
Int. Cl. A61K 41/00 (2020.01); A61K 9/127 (2006.01); A61N 7/00 (2006.01); A61K 47/24 (2006.01); A61K 47/12 (2006.01)
CPC A61K 41/0033 (2013.01) [A61K 9/1271 (2013.01); A61K 47/12 (2013.01); A61K 47/24 (2013.01); A61N 7/00 (2013.01); A61N 2007/0039 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A freeze-dried formulation, for preparing gas-filled microvesicles, comprising a mixture of the following lipid components: (a) distearoyl-phosphatidylcholine (DSPC), (b) dipalmitoylphosphatidyl-ethanolamine conjugated with polyethyleneglycol having a Mw of 5000 g/mol (DPPE-PEG5000) and (c) palmitic acid; said lipid components being in a respective molar amount a/b/c of 65 to 85/4 to 10/8 to 22,
wherein the formulation further comprises polyethylene glycol 4000 g/mol (PEG4000), and wherein the mixture of lipid components has a weight of from more than 0.3% to 0.5% with respect to the weight of PEG4000.