US 11,717,546 B2
Composition for promoting defecation and use therefor
Hsieh-Hsun Ho, Tainan (TW); Ching-Wei Chen, Tainan (TW); Yi-Wei Kuo, Tainan (TW); Yu-Fen Huang, Tainan (TW); Jui-Fen Chen, Tainan (TW); and Cheng-Chi Lin, Tainan (TW)
Assigned to GLAC BIOTECH CO., LTD, Tainan (TW)
Filed by GLAC BIOTECH CO., LTD, Tainan (TW)
Filed on May 3, 2021, as Appl. No. 17/246,977.
Claims priority of application No. 109121775 (TW), filed on Jun. 29, 2020.
Prior Publication US 2021/0401908 A1, Dec. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/747 (2015.01); A61P 1/10 (2006.01); A23L 33/135 (2016.01); A61K 35/745 (2015.01); A61K 35/744 (2015.01); A23C 9/123 (2006.01)
CPC A61K 35/747 (2013.01) [A23C 9/1234 (2013.01); A23L 33/135 (2016.08); A61K 35/744 (2013.01); A61K 35/745 (2013.01); A61P 1/10 (2018.01)] 10 Claims
OG exemplary drawing
 
1. A method for improving constipation, comprising:
administering a composition to a subject in need thereof so as to provide synergistic effect on a stool water content increase with the subject;
wherein the composition comprises: a fermentation powder of lactic acid bacteria; and a physiologically acceptable excipient, diluent, or carrier;
wherein the fermentation powder comprises: a fermentation product of lactic acid bacteria, and the fermentation product is a fermented supernatant of a culture medium containing inactivated strains, a fermented supernatant of a culture medium free of strains, or a powder thereof;
wherein the fermentation product is obtained by incubating lactic acid bacterial strains in a culture medium containing milk, milk powders, casein, soy beans, bean products, or whey, then performing centrifugation on the culture medium to obtain a fermentation liquid, and then inactivating the strains in the fermentation liquid or filtering out the strains in the fermentation liquid;
wherein the lactic acid bacterial strains comprise: a Lactobacillus salivarius subsp. salicinius AP-32 strain, a Lactobacillus plantarum LPL28 strain, a Lactobacillus acidophilus TYCA06 strain, and a Bifidobacterium longum subsp. infantis BLI-02 strain;
wherein the Lactobacillus salivarius subsp. salicinius AP-32 strain is deposited at the China Center for Type Culture Collection (CCTCC) under an accession number CCTCC M2011127, the Lactobacillus plantarum LPL28 strain is deposited at the China General Microbiological Culture Collection Center (CGMCC) under an accession number CGMCC 17954, the Lactobacillus acidophilus TYCA06 strain is deposited at the China General Microbiological Culture Collection Center under an accession number CGMCC 15210, and the Bifidobacterium longum subsp. infantis BLI-02 strain is deposited at the China General Microbiological Culture Collection Center under an accession number CGMCC 15212.