CPC A61K 35/74 (2013.01) [A61P 35/00 (2018.01); C07K 14/255 (2013.01); C12N 1/20 (2013.01); C12N 9/1205 (2013.01); C12Y 207/0104 (2013.01)] | 15 Claims |
1. A genetically modified tumoricidal Salmonella bacterium, wherein the bacterium is a self-eradicating, genetically modified χ3761 Salmonella bacterium comprising
ΔPmurA25::TT araC PBAD murA,
Δ(wcaM-wca)-8 ΔrelA198::araC PBAD laclTT,
Δ(araC PBAD)-18::P22 PR araBAD,
ΔpagP81::Plpp IpxE,
ΔendA1123 ΔPtar::Ptrc ΔlacO888 tar,
ΔPtsr::Ptrc ΔlacO888 tsr,
Δtrg,
ΔpvkA,
and ΔpykF, wherein the bacterium comprises a lysis vector pYA3681 expressing murA in the presence of arabinose, the lysis vector comprising pBR ori araC* PBAD SD-GTG asdA SD-GTG murA P22 PR anti-sense mRNA.
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