CPC A61K 31/722 (2013.01) [A61K 47/61 (2017.08); A61L 26/0023 (2013.01); A61L 26/0066 (2013.01); C08L 5/08 (2013.01); A61L 2300/404 (2013.01); A61L 2300/41 (2013.01); A61L 2300/64 (2013.01)] | 19 Claims |
1. A method of treating a wound in the eye of a subject, the method comprising topically administering to the eye of the subject an effective amount of an aqueous pharmaceutical composition comprising:
dextrose;
sterile water; and
a soluble derivatized chitosan, wherein the derivatized chitosan is of the following formula (I):
wherein:
n is an integer between 20 and 6000; and
each R1 is independently selected for each occurrence from hydrogen, acetyl,
wherein at least 25% of R1 substituents are H, at least 1% of R1 substituents are acetyl, and at least 2% of R1 substituents are
wherein the molecular weight of the derivatized chitosan is between about 10,000 and 350,000 Da,
wherein 36 hours after administration of the aqueous pharmaceutical composition, the eye wound has lower cumulative corneal scores compared to an eye wound treated with a composition consisting essentially of dextrose and sterile water,
thereby treating the wound in the eye of the subject.
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