US 11,717,521 B2
Compounds and methods for treating or preventing anterior segment ocular disorders and/or retinal degenerations
Mark Fields, New Haven, CT (US); Lucian Del Priore, Tarrytown, NY (US); Huey Cai, Montville, NJ (US); and Denton Hoyer, West Haven, CT (US)
Assigned to YALE UNIVERSITY, New Haven, CT (US)
Filed by YALE UNIVERSITY, New Haven, CT (US)
Filed on Jul. 8, 2020, as Appl. No. 16/923,492.
Application 16/923,492 is a continuation in part of application No. PCT/US2019/012749, filed on Jan. 8, 2019.
Claims priority of provisional application 62/614,757, filed on Jan. 8, 2018.
Claims priority of provisional application 62/716,546, filed on Aug. 9, 2018.
Prior Publication US 2020/0338081 A1, Oct. 29, 2020
Int. Cl. A61K 47/40 (2006.01); A61K 9/00 (2006.01); A61K 31/519 (2006.01); A61K 9/19 (2006.01)
CPC A61K 31/519 (2013.01) [A61K 47/40 (2013.01); A61K 9/0051 (2013.01); A61K 9/19 (2013.01)] 9 Claims
 
1. A method of treating or ameliorating retinal degeneration in a subject,
the method comprising administering topically to the eye of the subject an ophthalmologically acceptable pharmaceutical composition comprising ciclopirox (6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone), or a salt or solvate thereof, and at least one compound selected from the group consisting of hydroxypropyl-alpha-cyclodextrin and hydroxypropyl-beta-cyclodextrin.