	US 11,717,508 B2
	Compounds, compositions, and methods for inhibiting bacterial growth
Robert Abramovitch, East Lansing, MI (US); Huiqing Zheng, Lansing, MI (US); Christopher J. Colvin, East Lansing, MI (US); and Benjamin K. Johnson, Lansing, MI (US)
Assigned to Board of Trustees of Michigan State University, East Lansing, MI (US)
Appl. No. 16/339,896
Filed by Board of Trustees of Michigan State University, East Lansing, MI (US)
PCT Filed Oct. 5, 2017, PCT No. PCT/US2017/055244 § 371(c)(1), (2) Date Apr. 5, 2019, PCT Pub. No. WO2018/067769, PCT Pub. Date Apr. 12, 2018.
Claims priority of provisional application 62/404,492, filed on Oct. 5, 2016.
Prior Publication US 2020/0046678 A1, Feb. 13, 2020
Int. Cl. A61K 31/357 (2006.01); A61K 31/167 (2006.01); A61K 31/381 (2006.01); A61K 31/4184 (2006.01); A61K 31/42 (2006.01); A61K 31/473 (2006.01); A61K 31/496 (2006.01); A61K 31/133 (2006.01); A61K 31/4409 (2006.01); A61K 31/4965 (2006.01)

CPC A61K 31/357 (2013.01) [A61K 31/167 (2013.01); A61K 31/381 (2013.01); A61K 31/4184 (2013.01); A61K 31/42 (2013.01); A61K 31/473 (2013.01); A61K 31/496 (2013.01); A61K 31/133 (2013.01); A61K 31/4409 (2013.01); A61K 31/4965 (2013.01)]

8 Claims

1. A method for inhibiting growth of one or more mycobacterial cells in which an at least two-component regulatory system is conserved, said two-component regulatory system comprises one or more sensor histidine kinase and a cognate response regulator, the method comprising contacting the one or more mycobacterial cells with an effective amount of a compound that inhibits the at least two component regulatory system to thereby inhibit the growth of the one or more mycobacterial cells;

wherein the compound that inhibits the at least two-component regulatory system is an anti-virulence compound or analogs or derivatives thereof selected from the group consisting of HC101C, HC102A, HC103A, HC103B, HC104A, HC105A, and HC106A, or combinations thereof.