US 11,717,488 B2
Particle formation and morphology
Paul Brown, Boston, MA (US); Lyndon Fitzgerald Charles, Jr., Medford, MA (US); Chase Spenser Coffman, Newton, MA (US); Daniel Benjamin Dadon, East Boston, MA (US); James Ivey, Somerville, MA (US); Lisa Liu, Somerville, MA (US); and Chaitanya Sudrik, Stoneham, MA (US)
Assigned to Elektrofi, Inc., Boston, MA (US)
Filed by Elektrofi, Inc., Boston, MA (US)
Filed on Jun. 18, 2021, as Appl. No. 17/351,937.
Application 17/351,937 is a continuation of application No. PCT/US2020/015957, filed on Jan. 30, 2020.
Claims priority of provisional application 62/799,696, filed on Jan. 31, 2019.
Prior Publication US 2021/0315827 A1, Oct. 14, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/69 (2017.01); C07K 17/00 (2006.01); C07K 16/00 (2006.01); A61K 9/51 (2006.01)
CPC A61K 9/51 (2013.01) [C07K 16/00 (2013.01)] 16 Claims
 
1. A particle comprising at least one antibody or a fragment thereof, an amino acid, a carbohydrate, a salt, and a surfactant, wherein the circularity of the particle is from about 0.80 to about 1.00, and wherein the particle has less than about 10% internal void space, a diameter of about 10 μm to about 50 μm, and greater than about 70% antibody or a fragment thereof by weight.