US 11,717,482 B2
Inhalable antimicrobial particles and methods of making the same
Scott Hammond Medina, State College, PA (US); and Andrew William Simonson, Kennett Square, PA (US)
Assigned to The Penn State Research Foundation, University Park, PA (US)
Filed by The Penn State Research Foundation, University Park, PA (US)
Filed on Aug. 30, 2022, as Appl. No. 17/823,239.
Application 17/823,239 is a continuation of application No. 16/619,490, granted, now 11,458,099, previously published as PCT/US2018/035942, filed on Jun. 5, 2018.
Claims priority of provisional application 62/515,019, filed on Jun. 5, 2017.
Prior Publication US 2022/0409542 A1, Dec. 29, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/10 (2006.01); A61K 38/17 (2006.01); A61K 38/14 (2006.01); A61K 9/16 (2006.01); A61P 31/06 (2006.01); A61K 9/19 (2006.01); A61K 31/131 (2006.01); A61K 31/4245 (2006.01); A61K 31/4409 (2006.01); A61K 31/496 (2006.01); A61K 31/4965 (2006.01); A61K 31/7036 (2006.01); A61K 31/704 (2006.01)
CPC A61K 9/1658 (2013.01) [A61K 9/1652 (2013.01); A61K 9/19 (2013.01); A61K 31/131 (2013.01); A61K 31/4245 (2013.01); A61K 31/4409 (2013.01); A61K 31/496 (2013.01); A61K 31/4965 (2013.01); A61K 31/704 (2013.01); A61K 31/7036 (2013.01); A61K 38/14 (2013.01); A61P 31/06 (2018.01)] 7 Claims
 
1. A method comprising administering a plurality of particles to an individual, wherein the plurality of particles comprise:
an anionic polymer matrix comprising heparin or N-acetyl heparin; and
a cationic polymer that is a polypeptide that has the sequence of KRWHWWRRHWVVW (SEQ ID NO:11);
wherein the anionic polymer matrix and cationic polymer together form the particles bound by electrostatic interactions between the anionic polymer matrix and the cationic polymer.