US 11,717,474 B2
Method of continuously producing cannabinol from cannabis plant and uses thereof
Jungyeob Ham, Gangneung-si (KR); Taejung Kim, Gangneung-si (KR); Bong Chul Chung, Seoul (KR); Sungdo Ha, Gangneung-si (KR); Seok Lee, Seoul (KR); Jin-Chul Kim, Gangneung-si (KR); Pilju Choi, Gangneung-si (KR); and Bong Geun Song, Gangneung-si (KR)
Assigned to KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, Seoul (KR)
Filed by KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, Seoul (KR)
Filed on Dec. 30, 2020, as Appl. No. 17/138,312.
Prior Publication US 2021/0196608 A1, Jul. 1, 2021
Int. Cl. A61K 36/00 (2006.01); A61K 8/49 (2006.01); C07D 311/80 (2006.01); A23L 33/105 (2016.01); A23L 5/30 (2016.01)
CPC A61K 8/498 (2013.01) [A23L 5/34 (2016.08); A23L 33/105 (2016.08); C07D 311/80 (2013.01); A23V 2002/00 (2013.01); A61K 2236/333 (2013.01); A61K 2236/37 (2013.01)] 17 Claims
 
1. A method of producing cannabinoids, the method comprising irradiating microwaves to a reaction mixture comprising a Cannabis sp. plant or an extract thereof, an acid, and a solvent in a reaction vessel,
wherein the microwave irradiation is carried out while flowing the reaction mixture from an inlet of the reaction vessel and out through an outlet of the reaction vessel,
wherein the Cannabis sp. plant or the extract thereof comprises one or more of CBD and THC, and the cannabinoid is one or more of THC and CBN,
wherein the reaction vessel is connected to a temperature control chamber for controlling the temperature inside the reaction vessel,
wherein the reaction vessel is contained in the temperature control chamber filled with a liquid to control a temperature of the reaction mixture,
wherein the temperature control chamber comprises a microwave-transparent material, and
wherein the acid is methanesulfonic acid (MSA), benzenesulfonic acid, naphthalenesulfonic acid, toluenesulfonic acid, para-toluenesulfonic acid (p-toluensulfonic acid, PTSA), camphor-10-sulfonic acid (CSA), or a mixture thereof.