US 11,717,392 B2
Modulation of inflammatory response following endovascular treatment
Mohammed Arif Iftekhar, Irvine, CA (US); Peter Costandi, Irvine, CA (US); Carlos Ortega, Irvine, CA (US); Chris Williams, Irvine, CA (US); and Craig Welk, Irvine, CA (US)
Assigned to Endologix LLC, Irvine, CA (US)
Appl. No. 17/49,932
Filed by Endologix LLC, Irvine, CA (US)
PCT Filed Apr. 22, 2019, PCT No. PCT/US2019/028538
§ 371(c)(1), (2) Date Oct. 22, 2020,
PCT Pub. No. WO2019/209731, PCT Pub. Date Oct. 31, 2019.
Claims priority of provisional application 62/661,569, filed on Apr. 23, 2018.
Prior Publication US 2021/0093440 A1, Apr. 1, 2021
Int. Cl. A61F 2/07 (2013.01); A61F 2/958 (2013.01)
CPC A61F 2/07 (2013.01) [A61F 2/958 (2013.01); A61F 2002/077 (2013.01); A61F 2210/0085 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A method of treating an aortic aneurysm of a patient with an endovascular graft system and mitigating post implant syndrome inflammation resulting therefrom, comprising:
placing at least one prosthesis in an aortic aneurysmal space, said prosthesis comprising a stent-graft and a double-walled filling structure, wherein the filling structure comprises an outer wall, an inner wall, and a fillable space between the outer wall and the inner wall;
radially expanding the stent-graft with an expansion balloon at a first pressure of at least about 180 mm Hg;
filling the filling structure with a first filling agent such that the filling structure expands and contacts a thrombus disposed in the aneurysmal space;
removing the first filling agent from filling structure;
filling the filling structure with a second filling agent such that the filling structure expands and contacts the thrombus;
radially expanding the stent-graft with an expansion balloon at a second pressure thereby causing the filling structure with the second filling agent to place an effective amount of pressure on the thrombus;
wherein the effective amount of pressure placed on the thrombus mitigates the effects of post implant syndrome associated with the prosthesis by reducing inflammation in the aneurysm.