US 11,716,992 B2
5A5B6C tricyclic spirolactone derivative, preparation method therefor and use thereof
Zhijin Fan, Tianjin (CN); Yujie Zhu, Tianjin (CN); Lai Chen, Tianjin (CN); Shuang Zhou, Tianjin (CN); Xiaofeng Guo, Tianjin (CN); Haixia Wang, Tianjin (CN); Bin Yu, Tianjin (CN); Nailou Zhang, Tianjin (CN); Qifan Wu, Tianjin (CN); Dongyan Yang, Tianjin (CN); and Bin Zhao, Tianjin (CN)
Assigned to NANKAI UNIVERSITY, Tianjin (CN)
Appl. No. 16/755,162
Filed by NANKAI UNIVERSITY, Tianjin (CN)
PCT Filed Mar. 14, 2018, PCT No. PCT/CN2018/079046
§ 371(c)(1), (2) Date Apr. 10, 2020,
PCT Pub. No. WO2019/071911, PCT Pub. Date Apr. 18, 2019.
Claims priority of application No. 201710963432.6 (CN), filed on Oct. 13, 2017.
Prior Publication US 2021/0289783 A1, Sep. 23, 2021
Int. Cl. A01N 43/12 (2006.01); A01N 43/90 (2006.01); A01N 55/00 (2006.01); C07D 307/93 (2006.01); C07D 493/04 (2006.01); C07F 7/18 (2006.01)
CPC A01N 43/12 (2013.01) [A01N 43/90 (2013.01); A01N 55/00 (2013.01); C07D 307/93 (2013.01); C07D 493/04 (2013.01); C07F 7/188 (2013.01)] 2 Claims
 
1. A 5A5B6C tricyclic spironolactone derivative with a formula shown as XI:

OG Complex Work Unit Chemistry
wherein: R1 is hydrogen, allyl, propargyl, Ac, AcO, t-BuOO—, methoxy, CH(CO2Et2, —CH2CO2Et or isopropenyl;
R2 is hydrogen, allyl, propargyl, Ac, AcO, t-BuOO—, methoxy, —CH2CO2Et or isopropenyl;
X is hydrogen, hydroxyl, OAc, allyl, or propargyl;
Y is hydrogen, hydroxyl, OAc, allyl, or propargyl;

OG Complex Work Unit Chemistry
is C═O or C═S; Z is hydrogen, hydroxyl, or chlorine;
W is hydrogen, hydroxyl, or chlorine;
R1 and W constitute

OG Complex Work Unit Chemistry
and
R2 and W constitute

OG Complex Work Unit Chemistry