US 11,716,427 B2
Microarrayer for dispensing reagent on a substrate and a method for obtaining images of the substrate during the operation of said microarrayer
Benjamin Mitchell, Northumberland (GB)
Assigned to Arrayjet Limited, Lothian (GB)
Appl. No. 16/640,114
Filed by Arrayjet Limited, Lothian (GB)
PCT Filed Sep. 5, 2018, PCT No. PCT/GB2018/052505
§ 371(c)(1), (2) Date Feb. 19, 2020,
PCT Pub. No. WO2019/048844, PCT Pub. Date Mar. 14, 2019.
Claims priority of application No. 1714266 (GB), filed on Sep. 5, 2017.
Prior Publication US 2020/0290007 A1, Sep. 17, 2020
Int. Cl. H04N 1/024 (2006.01); H04N 1/00 (2006.01); G06K 15/10 (2006.01)
CPC H04N 1/0005 (2013.01) [G06K 15/10 (2013.01); G06K 15/105 (2013.01); H04N 1/00082 (2013.01); H04N 1/00997 (2013.01); H04N 1/02418 (2013.01); H04N 1/02463 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A microarrayer for dispensing reagent onto a substrate, comprising a dispensing print head adapted to load reagent and provided with a plurality of nozzles to dispense said at least reagent on the substrate, wherein the print head is mounted in the microarrayer to allow the print head to move with respect to the substrate in subsequent, essentially, parallel print passes, wherein the print head moves during a first print pass between a first end of the substrate toward a second end of the substrate and during a subsequent printpass in the opposite direction, the microarrayer being characterised in that the microarrayer comprises a first camera adapted to move behind the print head during a print pass and a second camera adapted to move ahead of the print head during said print pass, the first and second cameras being adapted to obtain images of the substrate,
wherein the microarrayer is provided with processing means connected to the first and second cameras, to allow the processing means to process images obtained by said first and second cameras during the first print pass and to calculate parameters based on the processed images and relating to the reagent printed on the substrate,
wherein the microarrayer is provided with control means, connected to the processing means, and
wherein the control means are adapted to generate instructions for the print head, to alter the operation of said print head in the subsequent print pass, based on the calculated parameters.